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Motor function (see also Parkinson's models)

    Open Field
    • Rodents are placed in an open box where total activity, discrete movements, distance traveled and rearing are measured.
    • Sensitive to hippocampal damage, basal ganglia damage, and hindlimb dysfunction.
    • Apparatus : cage, video tracking systems
    • see : Activity

    Tail Suspension

    • Indicator of dysfunction in descending motor pathways. Orientation, direction of turning, and fore and hindlimb spasticity are evaluated.
    • Apparatus : Tail suspension systems
    • see :

    Grid Walk Test

    • Stride length, walking foot spread and resting foot spread are measured in this test of limb coordination. Especially sensitive to deficits in descending motor control.
    • Apparatus :
    • see :

    Beam Walking

    • Assessment of motor incoordination. Time required for an animal to pull itself into a balanced position on a narrow beam is recorded.
    • Âü°í¹®Çå : ILAR Journal V44(2) 2003 by Larry B. Goldstein, Model of Recovery of Locomotor Ability After Sensorimotor Cortex Injury in Rats.
    • Apparatus : The apparatus is constructed by elevating the surface of a 2.5 ¡¿ 122 cm wooden beam 75 cm above the floor with wooden supports. A 20 ¡¿ 25 ¡¿ 24 cm goal box with a 9.5-cm opening is located at one end of the beam.
    • see :

    Rotarod

    • Tests an animal's ability to remain on a rotating rod as the speed of rotation increases. Requires a high degree of sensorimotor coordination and is sensitive to damage in the basal ganglia and the cerebellum.
    • Apparatus : rota-rod
    • see : Rota-rod Treadmill

    Grip Strength

    • Forelimb and hindlimb muscle strength evaluated by the distance a bar on a strain gauge is pulled before paw-grip is released.
    • Apparatus : Grip strength meter
    • see : Grip Strength Meter

    Landing Foot Spread

    • Test of peripheral nerve damage (neuropathy). The animal is released from a height, and the distance between the hindfeet as the animal lands is recorded.
    • Apparatus :
    • see :