• Chronic ingestion of alcohol, causing widespread damage to diffuse cholinergic and aminergic projection systems.
• Arendt, T., Hennig, D., Gray, J.A. & Marchbanks, R.M. (1988) Loss of neurons in the rat basal forebrain projection system after prolonged intake of ethanol. Brain Research Bulletin 21:563-570
  
• Apparatus :
  
• see :
  

Lesions (by local injection of the excitotoxins, ibotenate, quisqualate and AMPA)

• Lesions (by local injection of the excitotoxins, ibotenate, quisqualate and AMPA) to the nuclei of origin of the forebrain cholinergic projection system (FCPS), which innervates the neocortex and hippocampal formation.
  
• Apparatus : Wire cages L x W x H = 21 x 21 x 23 cm
  
• see :
  

Transient cerebral ischaemia

• transient cerebral ischaemia, producing focal damage, especially in the CA1 pyramidal cells of the dorsal hippocampus; and lesions (by local injection of the neurotoxin, colchicine) to the granule cells of the dentrate gyrus.
  
• Apparatus : Wire cages L x W x H = 21 x 21 x 23 cm
  
• see :