|
Anesthetic Cocktails
(Xylazine/Ketamine combinations) |
|
Species |
Concentration of mixture
(mg/ml) |
Dosage
(mg/kg BW ) * |
Dose and Route
(unit of BW) * |
| |
ketamine |
xylazine |
acepromazine |
ketamine |
xylazine |
acepromazine |
|
|
Cat
Ferret |
50.0 |
7.1 |
2.1 |
11.2 |
1.6 |
0.5 |
Cat - 1ml/10 lbs IM
Ferret - 1ml/14.5kg |
|
Dog |
50.0 |
7.1 |
2.1 |
3.7 |
0.5 |
0.2 |
1ml/30 lbs IV
1ml/14.0kg |
|
Goat
Sheep |
47.6 |
4.8 |
4.8 |
1.8 |
0.2 |
0.2 |
1ml/ 60 lbs IV
1ml/28kg |
|
Mouse
Gerbil |
30.0 |
4.0 |
--- |
120-240 |
16-32 |
--- |
Mouse - 0.1-0.2ml/25gm IP
Gerbil - 0.3-0.6ml 75gm IP |
|
Pig
Mini Pig |
83.3 |
16.7 |
--- |
10.4 |
2.1 |
--- |
1 ml/ 8 kg IM |
|
Rabbit |
42.9 |
8.5 |
1.4 |
28.6 |
5.7 |
1.0 |
1ml / 1.5 kg IM |
|
Rat
Guinea Pig
Hamster |
60.0 |
8.0 |
--- |
24-48 |
3.2-6.4 |
--- |
Rat - 0.1-0.2ml/250gm IP
G.P. - 0.2-0.4ml/500gm IP,IM
Hamster - 0.05-0.1ml/125gm IP, IM |
* BW = Body Weight
|
Mouse Anesthesia |
|
Anesthetic |
Concentration |
Dose and Route |
Onset |
Duration of Surgical Anesthesia |
Mouse Cocktail
(Ketamine,Xylazine) |
Ketamine 30mg/ml
Xylazine 4mg/ml |
0.1 - 0.2ml/25gm (IM,IP) |
3 - 5 minutes |
30 - 40 minutes |
Isoflurane
(need precision vaporizer to deliver the agent) |
induction 4-5%
maintenance 1-2% |
Inhalation |
2-3 minutes |
until disconnected |
Halothane
(need precision vaporizer to deliver the agent) |
induction 4-5%
maintenance 1-2% |
Inhalation |
2-3 minutes |
until
disconnected |
| Medetomidine*
+ Ketamine |
Medetomidine
1mg/ml
Ketamine 100mg/ml |
M - 1 mg/kg IM
K = 75mg/kg |
2 minutes |
30 minutes |
Mouse Cocktail
(Ketamine, Xylazine) |
Ketamine 30mg and
Xylazine 4mg per ml of mouse cocktail |
0.1-0.2ml/25 gm
IP |
3-5 minutes |
30-40 minutes |
| Pentobarbital |
65mg/ml |
50mg/kg IP(40-90 range)
1.25mg/25gm |
5 minutes |
30 minutes |
| Rat Cocktail
(double strength mouse cocktail) |
Ketamine
60mg/ml and
Xylazine 8mg per ml of rat cocktail |
0.05-0.1ml/25 gmIP, IM |
3-5 minutes |
30-40 minutes |
*can be reversed with atipamezole (1mg/kg SC, IP or IV)
|
Mouse Analgesics |
|
Analgesic |
Brand Name |
Concentration |
Dose and Route |
Frequency |
| Acetaminophen |
Tylenol |
tablets & liquid
various concentrations |
300mg/kg PO
700mg/25g PO |
every 4 hrs |
| Aspirin |
Various |
tablets & liquid
baby aspirin = 125mg
adult = 325mg |
120mg/kg PO |
every 4 hrs |
| Buprenorphine |
Buprenex |
0.3mg/ml |
0.05-2.0mg/kg
SC, IP 0.00125-0.0600mg/25g SC |
every 8-12 hrs |
| Butorphanol |
Torbugesic |
10mg/ml |
1-5mg/kg SC |
every 6 hrs |
| Codeine/Tylenol
elixir |
Various |
120mg acetaminophen
12 mg codeine
in 5ml elixir |
1ml/ 100 ml
drinking PO H20 |
every 6 hrs |
| Nalbuphine |
Nubain |
10mg/ml |
4-8mg/kg IM, SC
0.1-0.2mg/25g IM |
every 4 hrs |
|
Rat Anesthesia |
|
Anesthesia |
Concentration |
Dose and Route |
Onset |
Duration of Surgical Anesthesia |
| Rat Cocktail
(Ketamine, Xylazine) |
Ketamine 60mg
and Xylazine 8mg per ml of cocktail |
0.1-0.2ml/250g
IM, IP |
3-5 minutes |
30-40 minutes |
| Isoflurane
(need precision vaporizer to deliver the agent) |
induction 4-5%maintenance 1-2% |
Inhalation |
2-3 minutes |
until
disconnected |
| Halothane
(need precision vaporizer to deliver the agent) |
induction 4-5%maintenance 1-2% |
Inhalation |
2-3 minutes |
until
disconnected |
| Medetomidine*
+ Fentanyl (combination) |
M = 1mg/ml
F
= 50?
gm/ml |
300mg/kg IP
300?
gm/kg IP |
2 minutes |
30 minutes |
| Medetomidine*
+ Ketamine |
M = 1mg/ml
K
= 100mg/ml |
0.5 mg/kg IM, SC
75mg/kg IP |
2 minutes |
30 minutes |
| Pentobarbital |
65mg/ml |
30 mg/kg
(7.5mg/250mg) 50mg/kg (10.5mg/250mg) |
5 minutes
5
minutes |
90 minutes
120 minutes |
| Telazol
(tiletamine
+ zolazepam) |
tiletamine
50mg/ml zolazepam 50mg/ml (1:1) |
20mg/kg IP, IM
5mg/250g IP, IM |
3-5 minutes |
30-60 minutes |
| Inactin (EMTU -
ethylmalonythiourea) |
100mg/ml saline
10% solution |
80mg/kg IP
20mg/250gm IP |
3-5 minutes |
3-4 hrs |
*can be reversed with atipamezole
(1mg/kg SQ ,IP or IV)
|
Rat Analgesics |
|
Analgesic |
Brand Name |
Concentration |
Dose and Route |
Frequency |
| Acetaminophen |
Tylenol |
Tablets or liquid |
110-300mg/kg PO
25-75mg/250g) |
every 4 hrs |
| Aspirin |
Various |
Tablets or liquid
baby = 125mg/tablet
adult = 325mg/tablet |
100mg/kg PO
2.5mg/250g) |
every 4 hrs |
| Buprenorphine |
Buprenex |
0.3mg/ml |
0.1-1.5 mg/kg
SC, IP 0.025-0.1mg/250g |
every 6-12 hrs |
| Butorphanol |
Torbugesic |
10mg/ml |
0.05-2 mg/kg SC
0.012-0.5mg/250g |
every 4 hrs |
| Nalbuphine |
Nubain |
10mg/ml |
1-2mg/kg IM
0.25-0.5mg/250g |
every 4 hrs |
|
Buprenorphine Jello
Recipe for rodent analgesia
Feed Jello
without the drug to get the animals accustomed to the Jello. |
Synapse Volume 25 #3, September 1992, pp36-37
1. Decide on the dose (0.1-0.5 mg/kg) is recommended.
(0.025-0.10mg/250g)
2 Determine dosage. Plan on one ml volume of Jello per average weight
of rat, thus, for example, 0.33 ml Buprenex per 0.66ml of jello/250g
rat.
3. Making enough Jello for twice daily dosing for up to 4 days.
Strawberry seems to be the favorite.
4. Follow the Jello recipe up to the part where you dissolve the
Jello in hot liquid. Reduce the volume of cold water by the volume of
Buprenex you will be adding first. Add the cold H2O. Wait until mixture
is less than 90F before adding Buprenorphine. Pour into ice cube trays @
4 ml/section. Freeze and administer 1 cube/4 rats twice daily.
5. Dose by giving 1/4 of a 4 ml cube per rat. place on cage floor on
top of rodent food. |
|
Rabbit
Anesthesia |
|
Anesthesia |
Concentration |
Dose and Route |
Onset |
Duration of Surgical Anesthesia |
| Rabbit Cocktail
(ketamine, xylazine and acepromazine) |
42.8mg/ml
1.4mg/ml
8.5mg/ml |
1ml/1.5kg IM |
5-10 minutes |
30 minutes |
| Pentobarbital |
65mg/ml |
28mg/kg IV |
1-2 minutes |
30-45 minutes |
| Isoflurane
(need precision vaporizer to deliver the agent) |
induction 4-5%maintenance 1-2% |
Inhalation |
2-3 minutes |
until
discontinued |
| Halothane
(need precision vaporizer to deliver the agent) |
induction 4-5%maintenance 1-2% |
Inhalation |
2-3 minutes |
until
discontinued |
| Ketamine
(sedative not analgesic) |
100mg/ml |
44mg/kg IM
15-20mg/kg IV |
5-10 minutes |
20 minutes |
| Ketamine and
Diazepam Valium (Diazepam) |
100mg/ml
10mg/ml |
K: 25mg/kg IM
D: 5mg/kg IM |
5-10 minutes |
20-30 minutes |
|
Anti-Cholinergic
drugs For Rabbits ** |
|
Drug |
Concentration |
Dose and Route |
|
|
| Atropine |
0.5mg/ml |
0.2-1mg/kg SC,
IM |
|
**Not an
anesthetic/analgesic |
| Glycopyrrolate |
0.2mg/ml |
0.1-0.2mg/kg SC,
IM |
|
**Not an
anesthetic/analgesic |
|
Rabbit
Analgesics |
|
Analgesic |
Brand Name |
Concentration |
Dose and Route |
Frequency |
| Buprenorphine |
Buprenex |
0.3mg/ml |
0.01-0.05mg/kg
SC, IM, IV |
every 8-12 hrs |
| Butorphanol |
Torbugesic |
10mg/ml |
0.05-2.0mg/kg
SC, IM |
every 4 hrs |
| Nalbuphine |
Nubain |
10mg/ml |
1-2mg/kg
IM,
SC, IV |
every 4-5 hrs |
|
Canine
Anesthesia |
|
Anesthesia |
Concentration |
Dose and Route |
Onset |
Duration of Surgical Anesthesia |
| Dog cocktail
(RAAK) *
(ketamine, xylazine, acepromazine, atropine) |
ketamine
50mg/ml xylazine 7.1mg/ml (Rompun)
acepromazine 2mg/ml
atropine 0.1mg/ml |
Dog: 1ml/30lb IV
1ml/14kg |
1-5 minutes |
30-45 minutes |
| Thiopental
(Pentothal) |
4% (40mg/ml) |
5-15mg/kg IV |
<1min. |
5-10minutes |
| Isoflurane |
induction 4-5%
maintenance 1-2% |
Inhalation |
3-5 minutes |
Until
disconnected |
| Halothane |
induction 4-5%
maintenance 1-2% |
Inhalation |
3-5 minutes |
Until
disconnected |
| Pentobarbital |
65mg/ml |
20-30mg/kg IV |
1-3 minutes |
40 minutes
(supplement as needed) |
RAAK * {Rompun (Xylazine)
{Atropine
{Acepromazine
{Ketamine
|
Canine
Analgesics |
|
Analgesic |
Brand Name |
Concentration |
Dose and Route |
Frequency |
| Aspirin |
Various |
Adult =
325mg/tablet |
10-25mg/kg PO |
every 8-12 hrs |
| Buprenorphine |
Buprenex |
0.3mg/ml |
0.01-0.02mg/kg
SC, IM |
every 8-12 hrs |
| Butorphanol |
Torbugesic |
10mg/ml |
0.2-1.2mg/kg
SC, IM 0.05-0.2mg/kg IV |
every 2-5 hrs |
| Ketoprofen |
Orudis
Ketofen |
50mg/tablet
100mg/ml |
1mg/kg PO, IV |
every 24 hrs |
| Nalbuphine |
Nubain |
10mg/ml |
0.5-2.0mg/kg
SC, IM, IV |
every 3-8 hrs |
| Phenylbutazone |
Butazolidin |
100mg/tablet |
15-22mg/kg PO
**not to exceed 800mg/day |
every 8-12 hrs |
| Rimadyl |
Carprofen |
various sizes |
1mg/lb PO
2.2mg/kg |
every 12 hrs |
| Fentanyl patch
(sustained analgesia) |
25?
gm patch for dogs <10kg, 50?
gm patch for dogs 10-20kg
75?
gm patch for dogs 20-30kg
100 ?
gm patch for dogs >30kg. |
Shave an area on the dorsal neck and
apply the patch. Cover with
vetwrap.
*Apply patch 24 hr prior to surgery to reach steady state.
Remove patch 3-5 days after date of
application. |
|
Feline
Anesthesia |
|
Anesthesia |
Concentration |
Dose and Route |
Onset |
Duration of Surgical Anesthesia |
| RAAK |
ketamine
50mg/ml xylazine 7.1mg/ml
acepromazine 2mg/ml
atropine 0.1mg/ml |
1cc/10lb IM |
5-10 minutes |
30-45 minutes |
| Isoflurane |
induction 4-5%
maintenance 1-2% |
Inhalation |
3-5 minutes |
Until
disconnected |
| Halothane |
induction 4-5%
maintenance 1-2% |
Inhalation |
3-5 minutes |
Until
disconnected |
| Ketamine +
Xylazine |
60 mg/ml
8
mg/ml |
0.1ml/lb IM |
3-5 minutes |
60 minutes |
| Pentobarbital |
65 mg/ml |
30mg/kg IV |
3 minutes |
30-60 minutes |
|
Feline
Analgesics |
|
Analgesic |
Brand Name |
Concentration |
Dose and Route |
Frequency |
| Buprenorphine |
Buprenex |
0.3mg/ml |
0.005-0.01mg/kg
SC, IM |
every 12 hrs |
| Butorphanol |
Torbugesic |
10mg/ml |
0.1-0.4mg/kg
SC, IM |
every 6 hrs |
| Fentanyl patch
(sustained analgesia) |
Uncover 1/2 to 2/3 of a 25?
gm patch Do not cut the patch as this alters the release rate. |
Applied to the shaven thorax. Use a small amount of super glue to each
corner to help adhesion. No bandage is required. You should apply the
patch 3-4 hours prior to surgery. The patch is then removed 3-5 days
later. Studies show steady serum levels that last at least 104 hours. Do
not use heating pads because this will
increase absorption. |
| Aspirin |
baby
aspirin |
125gm/tablet |
10mg/kg PO |
every 48-72
hrs (may cause serious side effects if given
more frequently) |
|
Primate
Anesthesia
(Species dependent) |
|
Anesthesia |
Concentration |
Dose and Route |
Onset |
Duration of Surgical Anesthesia |
| Isoflurane |
induction 4-5%
maintenance 1-2% |
Inhalation |
3-5 minutes |
Until disconnected |
| Halothane |
induction 4-5%
maintenance 1-2% |
Inhalation |
3-5 minutes |
Until disconnected |
| Ketamine |
100mg/ml |
10-15mg/kg IM |
3-5 minutes |
15-30 minutes |
| Ketamine + Acepromazine |
K:
100mg/ml A: 10mg/ml |
K:
10mg/kg IM A: 0.5-1.0mg/kg IM |
3-5 minutes |
15-45 minutes
(sedation) |
| Pentobarbital |
65mg/ml |
5-15mg/kg IV |
1-3 minutes |
30-45 minutes |
| Thiopental (Pentothal) |
4%
(40mg/kg) |
15-20mg/kg IV |
1-3 minutes |
15-30 minutes |
| Telazol |
tiletamine 50mg/ml
zolazepam (1:1) 50mg/ml |
2-6mg/kg IM, IV |
5-12 minutes |
30
minutes |
| |
|
PRIMATE ANALGESIC |
|
Analgesic |
Brand Name |
Concentration |
Dose and Route |
Frequency |
| Buprenorphine |
Buprenex |
0.3mg/ml |
0.01 mg/kg IM, IV |
every 12 hrs |
| Nalbuphine |
Nubain |
10mg/ml |
2.5-5mg/kg IM |
every 3-4 hrs |
|
Swine Anesthesia |
|
Anesthesia |
Concentration |
Dose and Route |
Onset |
Duration of Surgical Anesthesia |
| Isoflurane |
induction 4-5%
maintenance 1-2% |
Inhalation |
2-3 minutes |
until
disconnected |
| Halothane |
induction 4-5%
maintenance 1-2% |
Inhalation |
2-3 minutes |
until
disconnected |
| Pentobarbital |
65mg/ml |
25-35mg/kg IV |
2-5 minutes |
30 minutes |
| Pig Cocktail
(may add acepromazine 1mg/kg) |
Ketamine
83.3mg/ml Xylazine 16.67mg/ml |
1ml/8kg IM
(3ml/50lbs) |
5-10 minutes |
30-45 minutes |
| Telazol/Xylazine
(mix in same syringe) |
Xylazine 100
mg/ml Telazol 100mg/ml |
2 mg/kg IM
Xylazine 5 mg/kg IM Telazol |
2-5 minutes |
20-30 minutes |
| Thiopental
(Pentothal) |
4% 40mg/ml |
24-30mg/kg IV |
2 minutes |
15 minutes |
|
Swine Analgesics |
|
Analgesic |
Brand Name |
|
Dose and Route |
Frequency |
| Aspirin |
Various |
325 mg/tablet |
10-20mg/kg PO |
every 4 hrs |
| Buprenorphine |
Buprenex |
0.3mg/ml |
0.005-0.01mg/kg
IM, IV |
every 12 hrs |
| Butorphanol |
Torbugesic |
10mg/mg |
0.1-0.3mg/kg
SC, IM, IV |
every 2-5 hrs |
| Nalbuphine |
Nubain |
10mg/ml |
1-2mg/kg SC, IM |
every 8 hrs |
|
Sheep/Goat
Anesthesia |
|
Anesthesia |
Concentration |
Dose and Route |
Onset |
Duration of Surgical Anesthesia |
| Goat Cocktail |
Ketamine
47.6/ml Xylazine 4.8mg/ml
Acepromazine 4.8mg/ml |
1ml/60lbs IM |
5-10 minutes |
30-45 minutes |
| Isoflurane |
induction 4-5%
maintenance 1-2% |
Inhalation |
2-3 minutes |
until
disconnected |
| Halothane |
induction 4-5%
maintenance 1-2% |
Inhalation |
2-3 minutes |
until
disconnected |
| Ketamine/Valium
combination |
100mg/ml
Ketamine 10 mg/ml Valium |
K: 4 mg/kg IV
V: 0.5-1.0 mg/kg IV |
2 minutes |
For induction
and intubation |
| Pentobarbital |
65mg/ml |
25-30mg/kg IV |
2 minutes |
30-40 minutes |
| Thiopental
(Pentothal) |
4% 40mg/ml |
20mg /kg IV |
2 minutes |
15 minutes |
|
Sheep/Goat
Analgesics |
|
Analgesic |
Brand Name |
Concentration |
Dose and Route |
Frequency |
| Aspirin |
Various |
325mg/tablet |
100mg/kg PO |
every 12 hrs |
| Buprenorphine |
Buprenex |
0.3mg/kg |
0.005-0.01.5
SC, IM |
every 12 hrs |
| Butorphanol |
Torbugesic |
10mg/ml |
0.5mg/kg SC |
every 4 hrs |
| Nalbuphine |
Nubain |
10mg/ml |
1mg/kg SC, IM |
every 8 hrs |
|
Miscellaneous
Species |
|
Species |
Anesthesia |
Concentration |
Dose and Route |
Onset |
Duration of Surgical Anesthesia |
| Gerbil70-100g BW |
Mouse cocktail
ketamine/xylazine |
K: 30mg/ml
X: 4.0mg/ml |
0.3-0.6ml/75g IM |
3-5 minutes |
15-30 minutes |
| Gerbil |
Pentobarbital |
65mg/ml |
40-90mg/kg IP |
3-5 minutes |
30-50 minutes |
| Hamster
110-140g BW |
Rat cocktail
ketamine/xylazine |
K: 60mg/ml
X:
8mg/ml |
0.05-0.1ml/125g
IP |
3-5 minutes |
15-30 minutes |
| Hamster |
Pentobarbital |
65mg/ml |
60-90mg/kg IP |
3-5 minutes |
60-75 minutes |
| Guinea Pig
500-1000g BW |
Rat cocktail
ketamine/xylazine |
K: 60mg/ml
X:
8mg/ml |
0.2-0.4ml SC, IM
500g BW |
3-5 minutes |
15-30 minutes |
| Guinea Pig |
Isoflurane |
1-4% |
inhalation |
1-2 minutes |
until
disconnected |
| Guinea Pig |
Pentobarbital |
65mg /ml |
35-45mg/kg IP |
3-5 minutes |
30-60 minutes |
|
