Target
Chemical name
Catalog
CAS No.
기 타
Akt/PKB
  A-674563
SYN-1110
552325-73-2
  Akt1, PKA, CDK2 inhibitor
  17-AAG
A-6880
75747-14-7
  Tanespimycin; Inhibits Akt activation and HER2 expression
  Akt-I-1
SYN-1005
473382-39-7
  an Akt kinase inhibitor
  Akt-I-2
SYN-1006
473382-48-8
  Akti-1/2 an Akt kinase inhibitor
  GSK690693
SYN-1043
937174-76-0
  pan-AKT kinase inhibitor
  Merck-22-6
SYN-1118
12847-42-4
  Akt1(138nM), Akt2(212nM) inhibitor.
ALK
  Crizotinib
SYN-1139
877399-52-5
  PF-02341066
  TAE684
SYN-1159
761439-42-3
  NVP-TAE684, ALK inhibitor
ASK1
  S-99
SYN-1119
1124381-69-6
  PF-02341066
ATM
  KU55933
SYN-1051
587871-26-9
  selective ATP-competitive inhibitor of ATM
AUR
  AT9283
SYN-1011
896466-04-9
  inhibitor of the Aurora A and B kinases
  CYC-116
SYN-1034
693228-63-6
  multi-kinase inhibitor with antineoplastic activity
  Danusertib
SYN-1095
827318-97-8
  PHA-739358, inhibitor of all known Aurora kinases
  JNJ7706621
SYN-1048
443797-96-4
  dual inhibitor of CDK and Aurora kinases
  SNS-314
SYN-1081
1057249-41-8
  pan Aurora kinase inhibitor
  Tozasertib
SYN-1092
639089-54-6
  MK-0457, VX-680; PHA-739358, inhibits Aurora kinases
AXL
  R428
SYN-1131
1037624-75-1
  inhibits Axl with low nanomolar activity
Bcl-2
  ABT-737
SYN-1001
852808-04-09
  novel and potent pan Bcl-2 inhibitor
  Obatoclax
O-3077
803712-79-0
  antagonizing Bcl-2
Bcr-Abl
  Dasatinib
SYN-1036
302962-49-8
  BMS-354825, Sprycel; oral., against BCR-ABL and SRC kinases
  AP24534
SYN-1116
943319-70-8
  Pan-BCR-ABL Inhibitor
  Danusertib
SYN-1095
827318-97-8
  PHA-739358 ; a small molecule inhibitor of all known Aurora
  Imatinib
SYN-1046
220127-57-1
  CGP54148, ST1571, Gleevec
  Nilotinib
SYN-1057
641571-10-0
  AMN107, Tasigna ; oral
  PD173955
SYN-1061
260415-63-2
  ATP-competitive, dual Src/Abl kinase inhibitor
BTK
  Dasatinib
SYN-1036
302962-49-8
  BMS-354825, Sprycel; oral., against BCR-ABL and SRC kinases
CDK
  A-674563
SYN-1110
552325-73-2
  a potent, orally available Akt1 inhibitor
  Alvocidib
SYN-1040
146426-40-6
  Flavopiridol, HMR-1275 ; a cyclin-dependent kinase inhibitor e
  Alvocidib
A-3465
146426-40-6
  Flavopiridol, HMR-1275 ; a cyclin-dependent kinase inhibitor e
  BS194
SYN-1151
1092443-55-4
  selective, potent CDK2, CDK1, CDK5, CDK7, and CDK9 inhib.
  AT-7519
SYN-1010
902135-91-5
  AT7519 ; oral bioavailable small molecule
  JNJ7706621
SYN-1048
443797-96-4
  dual inhibitor of CDK and Aurora kinases
  PHA690509
SYN-1097
492445-28-0
  cyclin-dependent kinase A inhibitor
  Purvalanol
SYN-1070
212844-54-7
  NG95 ; cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1
  and cdk5-p35 inhibitor
  SNS-032
SYN-1080
345627-90-9
  BMS387032 ; novel cyclin-dependent kinase inhibitor
CHK
  AZD7762b
SYN-1017
860352-01-8
  potent ATP-competitive checkpoint kinase (CHK) inhibitor
CK2
  CX-4945
SYN-1109
1009820-21-6
  oral, potent and selective inhibitor of the protein kinase CK2.
DNA-PK
  KU57788
SYN-1096
503468-95-9
  potent and selective ATP-competitive inhibitor of DNA-PK
EGFR
  AV-412
SYN-1012
451492-95-8
  orally bioavailable dual kinase inhibitor
  BIBW-2992
SYN-1100
439081-18-2
  Tovok, Afatinib ; inhibits EGFR1 and EGFR2
  BIBW-2992
A-8644
439081-18-2
  Tovok, Afatinib ; inhibits EGFR1 and EGFR2
  BMS-599626
SYN-1142
714971-09-2
  AC-480 ; highly selective and potent pan-HER kinase inhibitor.
  Canertinib
SYN-1030
289499-45-2
  CI-1033, PD-183805; orally bioavailable EGFR inhibitor
  Erlotinib
SYN-1039
183319-69-9
  OSI-774, CP-358774, Tarceva ; inhibits EGFR tyrosine kinase
    autophosphorylation
  Gefitinib
SYN-1042
184475-35-2
  ZD1839, Iressa ; EGFR tyrosine kinase inhibitor
  Lapatinib
SYN-1052
231277-92-2
  GW572016, Tykerb ; ATP-competitive EGFR and HER2/neu
  (ErbB-2) dual tyrosine kinase inhibitor
  Neratinib
SYN-1140
698387-09-6
  irreversible tyrosine kinase inhibitor for HER2 and EGFR
  Pelitinib
SYN-1141
257933-82-7
  3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor
  TAK-285
SYN-1153
871026-44-7
  a novel investigational dual HER2/EGFR inhibitor
  Vandetanib
SYN-1090
443913-73-3
  ZD6474, Zactima ; tyrosine kinase inhibitor targeting
  the VEGFR and EGFR
FAK
  PF-562271
SYN-1064
717907-75-0
  a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2
FGFR
  AP24534
SYN-1116
943319-70-8
  a Pan-BCR-ABL Inhibitor
  Brivanib
SYN-1134
649735-46-6
  inhibitors VEGFR -1 , -2, -3, FGFR-1, -2 and -3
  Brivanib alaninate
SYN-1135
649735-63-7
  an ATP-competitive inhibitor of human VEGFR-2, FGFR-1, -2, -3
  CHIR-258
SYN-1029
405169-16-6
  TKI258, Dovitinib ; growth factor receptor kinase inhibitor for FLT3,
  c-KIT, VEGFR1/2/3, PDGFRß and CSF-1R
  Danusertib
SYN-1095
827318-97-8
  PHA-739358 ; inhibitor of all known Aurora kinases
  E7080
SYN-1038
417716-92-8
  orally active inhibitor of multiple receptor tyrosine kinases
  including VEGF, FGF and SCF receptors
  MK-2461
SYN-1149
917879-39-1
  a novel ATP-competitive multitargeted inhibitor of activated c-Met
  kinases (N1100Y, Y1230C, Y1230H, Y1235D, and M1250T)
  NVP-BGJ398
SYN-1152
872511-34-7
  inhibits FGFR-WT, FGFR2-WT, FGFR3-K650E, FGFR3-S249C
  and FGFR4-WT
  SU-5402
SYN-1084
215543-92-3
  a selective inhibitor of VEGFR2 (Flk-1/KDR) and FGFR1
  SU-6668
SYN-1085
252916-29-3
  TSU-68; a potent ATP-competitive PDGFR, VEGF and FGFR inhib.
  Vargatef
SYN-1091
656247-17-5
  BIBF 1120, Intedanib ; indolinone derivative that potently inhibits
  VEGFR, PDGFR and FGFR kinase activity inhibits
Flt3
  ABT-869
SYN-1002
796967-16-3
  Linifanib, AL-39324, RG3635 ; a potent, selective inhibitor of the
  VEGF and PDGF platelet-derived growth factor families of RTKs
  AC220
SYN-1003
950769-58-1
  Quizartinib ; a selective FMS-like tyrosine kinase-3 inhibitor
  AP24534
SYN-1116
943319-70-8
  a Pan-BCR-ABL Inhibitor
  Cabozantinib
SYN-1138
849217-68-1
  very potent, for VEGFR2, MET, Kit and FLT3-ITD
  CHIR-258
SYN-1029
405169-16-6
  TKI258, Dovitiniba ; highly potent, novel multitargeted GFRK
  inhibitor for FLT3, c-KIT, VEGFR1/2/3, PDGFRß and CSF-1R,
  MP-470
SYN-1056
850879-09-3
  Amuvatinib ; multi-targeted tyrosine kinase inhibitor
  Sunitinib
SYN-1086
341031-54-7
  Sutent, SU11248 ; multi-targeted tyrosine kinase inhibitor
  Tandutinib
SYN-1088
387867-13-2
  CT53518, MLN518 ; inhibits the autophosphorylation of FLT3 ,
  c-KIT and PDGF receptor tyrosine kinases
FMS
  AC220
SYN-1003
950769-58-1
  Quizartinib ; a selective FMS-like tyrosine kinase-3 (FLT3) inhib.
  CHIR-258
SYN-1029
405169-16-6
  TKI258, Dovitinib ; growth factor receptor kinase inhibitor for FLT3,
  c-KIT, VEGFR1/2/3, PDGFRß and CSF-1R
  JNJ-28312141
SYN-1154
885692-52-4
  an orally active tyrosine kinase inhibitor
  Ki20227
SYN-1049
623142-96-1
  a c-fms tyrosine kinase inhibitor
GSK-3
  SB-216763
SYN-1075
280744-09-4
  a potent and selective ATP-competitive inhibitor of GSK-3
HER2
  AV-412
SYN-1012
451492-95-8
  an orally bioavailable dual kinase inhibitor
  BIBW-2992
SYN-1100
439081-18-2
  Tovok, Afatinib ; generation tyrosine kinase inhibitor
  BMS-599626
SYN-1142
714971-09-2
  AC-480 ; highly selective and potent pan-HER kinase inhibitor.
  CP-724714
SYN-1033
383432-38-0
  an oral, selective and potent ErbB-2 (HER2) kinase inhibitor.
  Lapatinib
SYN-1052
231277-92-2
  GW572016, Tykerb ; ATP-competitive EGFR and HER2/neu
  (ErbB-2) dual tyrosine kinase inhibitor
  Mubritinib
SYN-1112
366017-09-6
  TAK-165; a potent, irreversible human ErbB2 inhibitor
  Pelitinib
SYN-1141
257933-82-7
  a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor
  TAK-285
SYN-1153
871026-44-7
  a novel investigational dual HER2/EGFR inhibitor
JAK
  AZ-960
SYN-1015
905586-69-8
  potent and selective small molecule inhibitor of JAK2 kinase.
  Baricitinib phosphate salt
SYN-1117
1187595-84-1
  LY3009104, INCB-28050
  CEP-33779
SYN-1156
1346168-57-7
  a highly selective, orally active inhibitor for JAK2
  GPLG0634
SYN-1158
1206161-97-8
  a novel inhibitor of JAK1 and JAK2
  INCB018424
SYN-1120
941678-49-5
  Ruxolitinib; JAK1 and JAK2 inhibitor
  Merck 5
SYN-1054
457081-03-7
  reversible ATP-competitive inhibitor of the JAK kinases Jak1,
  Jak2, Jak3, and Tyk2.
  Momelotinib
SYN-1035
1056634-68-4
  CYT387 ; a selective JAK2 inhibitor
  NVP-BSK805
SYN-1136
1092499-93-8
  a potent and selective quinoxaline JAK2 inhibitor
  TG101209
SYN-1103
936091-14-4
  a potent, small molecule JAK2-selective kinase inhibitor
  TG101348
SYN-1104
936091-26-8
  SAR-302503; inhibits JAK2V617F
  TG-46
SYN-1120
941678-49-5
  a JAK inhibitors
  TG-89
SYN-1107
936091-56-4
  JAK2, FLT3, RET, and JAK3 inhibitor
  Tofacitinib
SYN-1032
477600-75-2
  CP690550 ; a JAK3 kinase inhibitor
  Tofacitinib
T-1377
477600-75-2
  CP690550 Tasocitinib ; a JAK3 kinase inhibitor
  Tofacitinib Citrate Salt
T-1399
540737-29-9
  Tasocitinib Citrate ; a JAK3 kinase inhibitor
  Tyrphostin AG 490
T-9142
134036-52-5
  AG 490 Tyrphostin B42 ; a JAK2 kinase inhibitor
JNK
  AS-602801
SYN-1147
848344-36-5
  a novel, orally active JNK-1 inhibitor
  CC-401
SYN-1028
395104-30-0
  a second generation ATP-competitive anthrapyrazolone c-Jun
  N terminal kinase (JNK) inhibitor
KIT/c-KIT
  AC220
SYN-1003
950769-58-1
  Quizartinib a selective FMS-like tyrosine kinase-3 (FLT3) inhibitor
  AMG-25
SYN-1125
1003311-62-3
  potent inhibition of c-Kit
  Axitinib
SYN-1014
319460-85-0
  AG013736 a potent, orally bioavailable tyrosine kinase inhibitor
  inhibits VEGFR-1, VEGFR-2, VEGFR-3, PDGFR, and cKIT
  CHIR-258
SYN-1029
405169-16-6
  TKI258, Dovitinib ; growth factor receptor kinase inhibitor for FLT3,
  c-KIT, VEGFR1/2/3, PDGFRß and CSF-1R
  Masatinib
SYN-1053
790299-79-5
  AB1010, Masivet ; inhibite c-Kit, PDGFR and FGFR3.
  Motesanib
SYN-1055
453562-69-1
  AMG706
  MP-470
SYN-1056
850879-09-3
  Amuvatinib ; multi-targeted tyrosine kinase inhibitor
  Nilotinib
SYN-1057
641571-10-0
  AMN107, Tasigna ; oral
  Pazopanib
SYN-1058
444731-52-6
  GW786034, Votrient ; inhibitor VEGFR, PDGFR and c-kit.
  Sunitinib
SYN-1086
341031-54-7
  Sutent, SU11248 ; multi-targeted tyrosine kinase inhibitor
  Tandutinib
SYN-1088
387867-13-2
  CT53518, MLN518 ; inhibits the autophosphorylation of FLT3 ,
  c-KIT and PDGF receptor tyrosine kinases
Lck
  AMG-47a
SYN-1007
882663-88-9
  orally bioavailable potent inhibitor of Lck and T cell proliferation.
LIMK
  BMS-3
SYN-1023
-
  a potent inhibitor of the LIM kinase
  BMS-5
SYN-1024
-
  a potent inhibitor of the LIM kinase.
B-Raf
  PLX4720
SYN-1069
918505-84-7
  inhibits B-Raf(V600E)
  SB590885
SYN-1077
405554-55-4
  selective small molecule inhibitor of the B-Raf kinasea
  Sorafenib
SYN-1082
284461-73-0
  multikinase inhibitor Nexavar by Bayer
c-Ret
  MP-470
SYN-1056
850879-09-3
  Amuvatinib a potent, novel and orally active multi-targeted
  tyrosine kinase inhibitor ( c-kit, flt3, and PDGFR.)
MAPK
  RWJ-67657
SYN-1072
215303-72-3
  a orally active inhibitor of p38 mitogen-activated protein kinase.
  R1487
SYN-1101
449808-64-4
  SY-R1487 a p38 MAP kinase inhibitor
  SB202190
SYN-1073
152121-30-7
  potent and selective inhibitor of the p38α and β isoforms of p38
  mitogen-activated protein kinase.
  SB203580
SYN-1074
152121-47-6
  RWJ 64809, PB 203580
  SB242235
SYN-1076
193746-75-7
  a potent and selective p38 MAP kinase inhibitor
  SD-06
SYN-1078
271576-80-8
  a p38 MAP kinase inhibitor
  SD169
SYN-1079
1670-87-7
  an ATP-competitve isoenzyme-selective MAPK inhibitor
  TAK-715
SYN-1087
303162-79-0
  a potent specific inhibitor of the p38α MAP kinase
  VX702
SYN-1093
745833-23-2
  a novel p38 MAP kinase inhibitor
  VX745
SYN-1123
209410-46-8
  small-molecule inhibitor of MAPK
MEK
  AZD6244
SYN-1016
606143-52-6
  ARRY142886, Selumetiniba potent and selective ATP
  uncompetitive inhibitor of MEK 1/2
  CI-1040
SYN-1031
212631-79-3
  PD184352 inhibitor of MEK1/2
  Doramapimod, Free Base
D-2744
285983-48-4
  BIRB 796 a p38 MAP kinase inhibitor
  PD 0325901
SYN-1059
391210-10-9
 inhibition of the phosphorylation and activation of MAPK/ERK
  PD 184352, Free Base
P-8499
212631-79-3
  CI-1040; inhibitor of MEK or MAPKK.
  PD 98059
P-4313
167869-21-8
 selective and cell-permeable inhibitor of MAP kinase
  SB 202190, Free Base
S-1700
152121-30-7
  FHPI; inhibits p38 kinase activity
  SB 203580, Free Base
S-3400
152121-47-6
  specific inhibitor of the kinase known(as p38, p40, CSBP, or RK)
  Trametinib
T-8123
871700-17-3
  Selective inhibitor of the MEK-1 and MEK-2
  U0126
U-6770
109511-58-2
  Selective inhibitor of the MEK-1 and MEK-2
  VX-702
V-9366
745833-23-2
  a second-generation, orally active MAPK p38 inhibitor.
MET
  AMG-1
SYN-1143
913376-84-8
  a potent inhibitor of human c-Met and RON
  AMG-458
SYN-1144
913376-83-7
  a potent inhibitor of c-Met
  AMG-51
SYN-1111
890019-63-3
  enzyme selectivity of c-Met
  BMS-2
SYN-1022
888719-03-7
  a potent MET kinase inhibitor
  Cabozantinib
SYN-1138
849217-68-1
  XL184, BMS-907351 for VEGFR2, MET, Kit and FLT3-ITD
  mechanistic assays in cells
  Crizotinib
SYN-1139
877399-52-5
  PPF-02341066 potently inhibited cell proliferation
  JNJ38877605
SYN-1047
8943540-75-8
  c-MET tyrosine kinase inhibitor
  MK-2461
SYN-1149
917879-39-1
  ATP-competitive multitargeted inhibitor of activated c-Met kinases
  MP-470
SYN-1056
850879-09-3
  Amuvatinib active multi-targeted tyrosine kinase inhibitor
  PF04217903
SYN-1060
956905-27-4
  small molecule tyrosine kinase inhibitor
  SGX523
SYN-1155
1072116-01-8
  an exquisitely selective MET receptor tyrosine kinase inhibitor
  XL880
SYN-1129
849217-64-7
  GSK1363089, Foretinib, EXEL-2880
  MET and VEGFR2 kinase inhibitor
mTOR
  BEZ-235
SYN-1018
915019-65-7
  NVP-BEZ235 a dual inhibitor of PI3K and mTOR.
  BEZ-235
N-4288
915019-65-7
  NVP-BEZ235 inhibits PI3K and mTOR kinase activity
  Everolimus
E-4040
159351-69-6
  Afinitor, Certican, RAD001, SDZ-RAD, Zortress inhibitor of mTOR
  GDC0980
SYN-1150
1032754-93-0
  RG7422 dual PI3 Kinase and mTOR Kinase inhibitor
  GSK2126458
SYN-1126
1086062-66-9
  HYR-582 inhibitor of PI3K (α, β, γ, δ), mTORC1, and mTORC2.
  GNE 477
SYN-1148
938440-64-3
  a mixed mTOR/PI3k inhibitor
  INK128
SYN-1157
938440-64-3
  inhibitor of raptor-mTOR and rictor-mTOR
  KU0063794
SYN-1050
1224844-38-5
  highly specific inhibitor of the mammalian target of rapamycin
  PP242
P-6666
1092351-67-1
  Torkinib; an inhibitor at the kinase domain of the mTOR
  PP242
SYN-1181
1092351-67-1
  Torkinib; an inhibitor at the kinase domain of the mTOR
  Pimecrolimus
P-6040
137071-32-0
  Elidel, SDZ-ASM-981 ; an inhibitor of the mTOR
  Rapamycin
R-5000
53123-88-9
  AY-22989, LCP-Siro, RAPA, Rapamune, Sirolimus, SILA 9268A
  ; an inhibitor of mTOR
  Ridaforolimus
R-7040
572924-54-0
  9CI, AP 23573, Deforolimus, MK-8669 ; an inhibitor of mTOR
  Temsirolimus
T-8040
162635-04-3
  CCI-779, Torisel ; an inhibitor at the kinase domain of the mTOR
  XL765
SYN-1137
1123889-87-1
  SAR245409 dual PI3 Kinase and mTOR Kinase inhibitor
p38MAPK
  SB202190
SYN-1073
152121-30-7
  potent and selective inhibitor of the p38α and β isoforms of
  p38 mitogen-activated protein kinase
  R1487
SYN-1101
449808-64-4
  a p38 MAP kinase inhibitor
  RWJ-67657
SYN-1072
215303-72-3
  active inhibitor of p38 mitogen-activated protein kinase
  SB203580
SYN-1074
152121-47-6
  RWJ 64809, PB 203580 inhibitor of the stress- and inflammatory
  cytokine-activated MAP kinase homologues p38α, p38β, p38β2.
  SB242235
SYN-1076
193746-75-7
  potent and selective p38 MAP kinase inhibitor
  SD-06
SYN-1078
271576-80-8
  a p38 MAP kinase inhibitor
  SD169
SYN-1079
1670-87-7
  ATP-competitve, isoenzyme-selective MAPK inhibitor.
  TAK-715
SYN-1087
303162-79-0
  specific inhibitor of the p38α MAP kinase
  VX702
SYN-1093
745833-23-2
  a novel p38 MAP kinase inhibitor
PDGFR
  ABT-869
SYN-1002
796967-16-3
  Linifanib, AL-39324, RG3635 inhibitor of the VEGF and PDGF
  AC220
SYN-1003
950769-58-1
  Quizartinib a selective FMS-like tyrosine kinase-3 (FLT3) inhibitor
  Axitinib
SYN-1014
319460-85-0
  AG013736 inhibitors of VEGFR-1~3, PDGFR, cKIT
  Axitinib
A-1107
319460-85-0
  AG013736 inhibitors of VEGFR-1~3, PDGFR, cKIT
  Cabozantinib
SYN-1138
849217-68-1
  XL184, BMS-907351 very potent for VEGFR2, MET, Kit and
  FLT3-ITD mechanistic assays in cells
  CHIR-258
SYN-1029
405169-16-6
  TKI258, Dovitiniba ; highly potent, novel multitargeted GFRK
  inhibitor for FLT3, c-KIT, VEGFR1/2/3, PDGFRß and CSF-1R,
  JNJ-10198409
J-4567
627518-40-5
  RWJ 540973 inhibitor of PDGF-RTK
  Motesanib
SYN-1055
453562-69-1
  AMG706 inhibitor of human VEGFR1-3, PDGFR and c-KIT.
  MP-470
SYN-1056
850879-09-3
  Amuvatinib inhibits c-kit, flt3, and PDGFR
  Nilotinib
SYN-1057
641571-10-0
  AMN107, Tasigna aminopyrimidine-derivative Bcr-Abl tyrosine
  kinase inhibitor
  Pazopanib
SYN-1058
444731-52-6
  GW786034, Votrient inhibitor of VEGFR, PDGFR and c-kit
  SU-6668
SYN-1085
252916-29-3
  TSU-68 ATP-competitive PDGFR, VEGF and FGFR inhibitor
  Sunitinib
SYN-1086
341031-54-7
  Sutent, SU11248 ; multi-targeted tyrosine kinase inhibitor
  Tandutinib
SYN-1088
387867-13-2
  CT53518, MLN518 ; inhibits the autophosphorylation of FLT3 ,
  c-KIT and PDGF receptor tyrosine kinases
  Vargatef
SYN-1091
656247-17-5
  BIBF 1120, Intedanib ; indolinone derivative that potently inhibits
  VEGFR, PDGFR and FGFR kinase activity inhibits
PDK
  BX795
SYN-1026
702675-74-9
  a PDK1 inhibitor
  BX912
SYN-1027
9702674-56-4
  a PDK1 (3-Phosphoinositide-dependent Kinase-1) inhibitor
PI3K
  AS-252424
SYN-1009
900515-16-4
  a potent and selective PI3Kγ inhibitor
  BEZ-235
SYN-1018
915019-65-7
  NVP-BEZ235 a dual inhibitor of PI3K and mTOR
  CH5132799
SYN-1146
1007207-67-1
  selectively inhibits class I PI3K and PI3Kα mutants
  GDC-0941
SYN-1041
957054-30-7
  a potent class I PI3 kinase (PI3K) inhibitor
  GDC-0941
G-9252
957054-30-7
  Pictilisib; a phosphatidylinositol 3-kinase (PI3K) inhibitor
  GDC0980
SYN-1150
1032754-93-0
  RG7422selective, dual PI3 Kinase and mTOR Kinase inhibitor
  GNE 477
SYN-1148
1032754-81-6
  a potent and efficacious dual PI3K/mTOR inhibitor
  GNE-490
SYN-1114
1033739-92-2
  a highly selective pan-PI3K inhibitor
  GNE-493
SYN-1115
1033735-94-2
  pan-PI3-kinase and dual pan-PI3-kinase/mTOR inhibitors
  GSK2126458
SYN-1126
1086062-66-9
  HYR-582 inhibitor of PI3K (α, β, γ, δ), mTORC1, and mTORC2
  IC87114
SYN-1045
371242-69-2
  an isoform-selective PI3K inhibitor.
  LY294002
SYN-1108
154447-36-6
  a selective and reversible PI3K inhibitor
  LY294002
L-7962
154447-36-6
  a selective and reversible PI3K inhibitor
  NIBR-17
SYN-1145
944396-88-7
  a pan class I PI3K inhibitor
  NVP-BEZ235
N-4288
915019-65-7
  BEZ235; inhibits PI3K and mTOR kinase activity
  PI103
SYN-1065
371935-74-9
  an isoform-selective class I PI3K and mTOR inhibitor
  PIK-75
SYN-1067
372196-67-3
  a PI3K inhibitor displaying selectivity for the p110α isoform
  PIK-75, Hydrochloride Salt
P-7050
372196-77-5
  PI3-Kinase α Inhibitor VIII; a PI3K inhibitor
  PIK-90
SYN-1068
677338-12-4
  a potent PI3K inhibitor
  PIK-90
P-9050
677338-12-4
  a potent PI3K inhibitor
  PIK-93
SYN-1066
593960-11-3
  inhibits the type III PI 4-kinase β enzyme
  PIK-294
SYN-1098
900185-02-6
  a PI3 Kinase inhibitor
  PX-866
P-7501
502632-66-8
  DJM-166 DJM-2-166 a PI3 Kinase inhibitor
  TG100115
SYN-1105
677297-51-7
  inhibits PI3Kγ and -δ,
  TGX221
SYN-1089
663619-89-4
  a potent, cell permeable ATP-competitive inhibitor of PI3K
  Wortmannin
W-2990
19545-26-7
  KY 12420; irreversible, and specific inhibitor of PI3K
  XL147
SYN-1127
956958-53-5
  SAR245408 ; selective inhibitor of class I PI3K
  XL765
SYN-1137
1123889-87-1
  SAR245409 ; a mixed mTOR/PI3k inhibitor
  ZSTK474
SYN-1099
475110-96-4
  Inhibits all four PI3K isoforms in an ATP-competitive manner
  ZSTK474
Z-1066
475110-96-4
  Inhibits all four PI3K isoforms in an ATP-competitive manner
PIKFYVE
  YM201636
SYN-1094
371942-69-7
  a cell-permeable and selective inhibitor of PIKfyve
Pim
  SMI-4a
SYN-1113
438190-29-5
  a novel, ATP-competitive inhibitor of Pim kinases.
  CX6258
SYN-1182
438190-29-5
  the potent inhibitors of Pim-1, Pim-2 and Pim-3 kinase inhibitor .
PKA
  Fasudil, Monohydrochloride
F-4660
105628-07-7
  HA-1077 Eril AT-877; a potent PKA inhibitor
  H-89, Dihydrochloride
H-5239
127243-85-0
  Potent and selective inhibitor of PKA
  HA-1077, Dihydrochloride
H-2330
203911-27-7
  [Fasudil, Dihydrochloride Eril AT-877 HA1077inhibitor of PKA
  K252a
K-2151
97161-97-2
  a kinase inhibitor that inhibits PKA
  K252c
K-9609
85753-43-1
  Staurosporinone K-252c inhibitor of PKA
  Protein Kinase A Inhibit.(6-22) amide
86-0-20
-
  Inhibitor of cAMP dependent protein kinase.
  Rp-cAMPS
A 002
151837-09-1
  inhibitor of PKA type I and II (cyclic AMP antagonist).
  Staurosporine
S-9300
62996-74-1
  Antibiotic AM-2282 inhibitor of PKA & PKC
PKC
  Bisindoylmaleimide X
SYN-1021
-
  Ro 31-8425 ; a potent and selective protein kinase C (PKC)
  5- Iodotubercidin ( 5-I-Tu )
I 004
24386-93-4
  Potent inhibitor of adenosine kinase and other protein kinases
  Enzastaurin
E-4506
170364-57-5
  LY-317615 D04014 inhibits PKCβ, PKCα, PKCγ and PKCε
  Go 6976
G-6203
136194-77-9
  PD 406976 Go 6976; Novel, very potent PKC inhibitor with high
  selectivity for the A-group of PKC isotypes (α, β, and γ)
  H-89, Dihydrochloride
H-5239
127243-85-0
  Potent and selective inhibitor of PKC
  K252a
K-2151
97161-97-2
  a kinase inhibitor that inhibits PKA
  K252c
K-9609
85753-43-1
  Staurosporinone K-252c inhibitor of PKC
  PKC412
P-7600
120685-11-2
  CGP41251 Midostaurin inhibitor of PKC
  Staurosporine
S-9300
62996-74-1
  Antibiotic AM-2282 inhibitor of PKA & PKC
PKG
  Fasudil, Monohydrochloride
F-4660
105628-07-7
  HA-1077 Eril AT-877; a potent PKG inhibitor
  HA-1077, Dihydrochloride
H-2330
203911-27-7
  [Fasudil, Dihydrochloride Eril AT-877 HA1077inhibitor of PKG
  K252a
K-2151
97161-97-2
  a kinase inhibitor that inhibits PKG
  PKG inhibitor peptide DT-2
D 051
-
  Peptide-based inhibitor of protein kinase G
  PKG inhibitor peptide (D)-DT-2
D 110
-
  Potent peptide-based inhibitor of protein kinase G Iα and Iβ
  PKG inhibitor peptide DT-3
D 052
-
  Peptide-based inhibitor of protein kinase G
  PKG inhibitor peptide W45
W 001
-
  Peptide-based, membrane-impermeant inhibitor of protein
  kinase G Iα and Iβ
  Rp-8-Br-cGMPS
B 005
150418-07-8
  PDE-resistant inhibitor of protein kinase G I α and I ß
  Rp-8-pCPT-PET-cGMPS
C 046
1262749-62-1
  Potent, PDE-resistant inhibitor of protein kinase G
  Staurosporine
S-9300
62996-74-1
  Antibiotic AM-2282 inhibitor of PKG & PKC
PLK-1
  (R)-BI-2536
SYN-1019
755038-02-9
  a potent small-molecule inhibitor of mammalian Plk1
PYK2
  PF431396
SYN-1063
717906-29-1
  a potent pyrimidine-based PYK2 inhibitor
  PF-562271
SYN-1064
717907-75-0
  ATP-competitive, reversible inhibitor of FAK and Pyk2
ROCK
(Rho)
  GSK-25
SYN-1124
874119-56-9
  good selectivity against a panel of 31 kinases, as well as RSK1
  and p70S6
  Fasudil
F-4660
105628-07-7
  Fasudil, Eril, AT-877 ; inhibitor of Rho-associated kinase II
  HA-1077, Dihydrochloride
H-2330
203911-27-7
  Fasudil, Eril, AT-877 ; inhibitor of Rho-associated kinase II
  RHO-15
SYN-1071
864082-47-3
  GSK429286A ; inhibitor of Rho-associated kinase (ROCK1)
  SR3677
SYN-1083
1072959-67-1
  a potent and selective ROCK-II inhibitor
RON
  AMG-1
SYN-1143
913376-84-8
  a potent inhibitor of human c-Met and RON
RSK
  BI-D1870
SYN-1020
501437-28-1
  specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms
  RSK1, RSK2, RSK3 and RSK4
RTK
  PF-56227
SYN-1064
717907-75-0
  ATP-competitive, reversible inhibitor of FAK and Pyk2
S6K
  S6K-18
SYN-1132
1265789-88-5
  a highly selective inhibitor of S6K1
SCFR
  E7080
SYN-1038
417716-92-8
  active inhibitor of multiple receptor tyrosine kinases including
  VEGF, FGF and SCF receptors
Src
  Dasatinib
SYN-1036
302962-49-8
  BMS-354825, Sprycel multitargeted kinase inhibitor that is active
  against BCR-ABL and SRC family kinases
  PD173955
SYN-1061
260415-63-2
  an ATP-competitive, dual Src/Abl kinase inhibitor
  PD173955-Analog1
SYN-1062
185039-99-0
  a potent c-Src inhibitor
SYk
  R406
SYN-1121
841290-80-0
  inhibited phosphorylation of Syk substrate linker for activation of
  T cells
  R788
SYN-1122
1025687-58-4
  Fostamatinib, FosD, tamatinib fosdium inhibits BCR signaling
TBK1
  BX795
SYN-1026
702675-74-9
  a potent and relatively specific inhibitor of TBK1 and IKKε
TEC
  Dasatinib
SYN-1036
702675-74-9
  BMS-354825, Sprycel ; multitargeted kinase inhibitor that is
  active against BCR-ABL and SRC family kinases
TIE
  AMG-Tie2-1
SYN-1008
870223-96-4
  a highly potent, non-selective inhibitor of Tie-2
  AP24534
SYN-1116
943319-70-8
  a Pan-BCR-ABL Inhibitor
  Cabozantinib
SYN-1138
849217-68-1
  VEGFR2, MET, Kit and FLT3-ITD mechanistic assays in cells.
TRKA
  GW441756
SYN-1044
504433-23-2
  highly selective TrkA tyrosine kinase inhibitor
  GNF-5837
SYN-1183
504433-23-2
  selective and orally bioavailable pan-TRK inhibitor of TRKA, TRKB
  and TRKC
TYK2
  Bayer-18
SYN-1130
1251752-12-1
  a selective TYK2 inhibitor
  RO495
SYN-1128
1258296-60-4
  a very potent TYK2 inhibitor on TYK2 enzyme.
VEGFR
  ABT-869
SYN-1002
796967-16-3
  Linifanib, AL-39324, RG3635 inhibitor of the VEGF and PDGF
  AG13958
SYN-1004
319460-94-1
  a VEGF inhibitor
  AP24534
SYN-1116
943319-70-8
  Pan-BCR-ABL Inhibitor
  Axitinib
SYN-1014
319460-85-0
  AG013736 inhibitors of VEGFR-1~3, PDGFR, cKIT
  Axitinib
A-1107
319460-85-0
  AG013736 inhibitors of VEGFR-1~3, PDGFR, cKIT
  Brivanib
SYN-1134
649735-46-6
  BMS-540215 inhibitors of VEGFR -2,VEGFR-1 and VEGFR-3
  Brivanib alaninate
SYN-1135
649735-63-7
  BMS-582664 an ATP-competitive inhibitor of human VEGFR-2
  Cabozantinib
SYN-1138
849217-68-1
  XL184, BMS-907351 very potent for VEGFR2, MET, Kit and
  FLT3-ITD mechanistic assays in cells
  CHIR-258
SYN-1029
405169-16-6
  TKI258, Dovitiniba ; highly potent, novel multitargeted GFRK
  inhibitor for FLT3, c-KIT, VEGFR1/2/3, PDGFRß and CSF-1R,
  E7080
SYN-1038
417716-92-8
  active inhibitor of multiple receptor tyrosine kinases including
  VEGF, FGF and SCF receptors
  Foretinib
F-4185
849217-64-7
  GSK1363089, XL-880, EXEL-2880a novel MET and VEGFR2
  kinase inhibitor
  JNJ-38158471
SYN-1133
951151-97-6
  highly selective VEGFR-2 inhibitor
  Motesanib
SYN-1055
453562-69-1
  AMG706 inhibitor of human VEGFR1-3, PDGFR and c-KIT.
  Pazopanib
SYN-1058
444731-52-6
  GW786034, Votrient inhibitor of VEGFR, PDGFR and c-kit
  Pazopanib
P-6706
444731-52-6
  GW786034, Armala inhibitor of VEGFR, PDGFR and c-kit
  Sorafenib
SYN-1082
284461-73-0
  Nexavar, BAY43-9006 a multikinase inhibitor targeting a number
  of serine/threonine and receptor tyrosine kinasesa
  SU-5402
SYN-1084
215543-92-3
  a selective inhibitor of VEGFR2 (Flk-1/KDR) and FGFR1
  SU-6668
SYN-1085
252916-29-3
  TSU-68 ATP-competitive PDGFR, VEGF and FGFR inhibitor
  Sunitinib
SYN-1086
341031-54-7
  Sutent, SU11248 ; multi-targeted tyrosine kinase inhibitor
  Vandetanib
SYN-1090
443913-73-3
  ZD6474, Zactima a tyrosine kinase inhibitor targeting
  VEGFR and EGFR.
  Vargatef
SYN-1091
656247-17-5
  BIBF 1120, Intedanib ; indolinone derivative that potently inhibits
  VEGFR, PDGFR and FGFR kinase activity inhibits
  Vargatef
I-9077
656247-17-5
  BIBF 1120, Intedanib ; indolinone derivative that potently inhibits
  VEGFR, PDGFR and FGFR kinase activity inhibits
  XL880
SYN-1129
849217-64-7
  GSK1363089, Foretinib, EXEL-2880a novel MET and VEGFR2
  kinase inhibitor