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Phase one reactions involve the addition or unmasking of a functional polar group, typically resulting in a relatively small increase in hydrophilicity. The CYP450 mixed function oxidases are microsomal enzymes that collectively are the most catalytically versatile and important phases one enzymes. The human genome encodes 60 distinct CYP450 genes that are grouped based on similarities in the amino acid sequences of these enzymes into 18 gene families that are divided into 42 subfamilies. The relative importance of the various members of CYP families 1-3 in human xenobiotic metabolism is represented in the figure below.
Purified Recombinant Enzymes
Cat. #
  Human CYP 1A2
PH 19
  Human CYP 2C10
PH 23
  Human CYP 2C19
PH 40
  Human CYP 2D6
PH 46
  Human CYP 2E1
PH 27
  Human CYP 3A4
PH 34
  P450 Oxidoreductase
PH 50
  Cytochrome b5
PH 90
Microsomes Containing Recombinant
Human P450x And P450 Reductase
Cat. #
  CYP 1A2
PD 14
  CYP 2D6
PD 15
  CYP 2C9
PD 24
  CYP 2C19
PD 25
  CYP 2D6
PD 27
  CYP 2E1
PD 32
  CYP 3A4
PD 34
  Control Microsomes
PD 36
 
Antibodies
Specifications
Cat. #
  CYP 1A1
Monoclonal Ig
PM 10
  CYP 1A1, 1A2
Goat Serum
PR 31
  CYP 1A2
Rabbit Serum
PA 17
  CYP 1A2
Goat Serum
PH 17
  CYP 2B1
Monoclonal
PM 25
  CYP 2B1/2B2
Monoclonal
PM 20
  CYP 2B4
Goat Serum
PR 30
  CYP 2C10
Rabbit Serum
PA 22
  CYP 2C11
Monoclonal
PM 30
  CYP 2E1
Rabbit Serum
PA 26
  CYP 2E1
Goat Serum
PR 32
  CYP 2E1
Monoclonal
PM 32
  CYP 3A1
Monoclonal
PM 40
  Cytochrome b5
Goat Serum
PH 91
Phase two reactions involve the conjugation of xenobiotics to a small hydrophilic endogenous substance (e.g. glutathione, glucuronic acid, or cysteine) to render it more hydrophilic, facilitating excretion. We offer an extensive and rowing line of antibodies to characterize phases two enzymes as well as an array of purified, recombinant, active proteins for in vivo studies.
Antibodies To
From
Cat. #
  GST A1-1
Rabit serum
GS 62
  GST A1-1
Goat Serum
GS 09
  GST M1-1
Rabit serum
GS 67
  GST M1-1
Goat Serum
GS 23
  GST P1-1
Rabit serum
GS 72
  GST (A+M+P)
Rabbit Serum
GS 80
Purified Enzymes
Specifications
Cat. #
  GST A1-1
Human Recombinant
GS 60
  GST A1-1
Bovine Recombinant
GS 85
  GST A2-2
Human Recombinant
GS 61
  GST A2-2
Rat Recombinant
GS 31
  GST A3-3
Human Recombinant
GS 63
  GST A3-3
Rat Recombinant
GS 33
  GST A4-4
Human Recombinant
GS 64
  GST M1-1
Human Recombinant
GS 65
  GST A3-3
Human Recombinant
GS 63
  GST M1(Yb2)
Rat, Purified Native
GS 22
  GST M2-2
Purified Recombinant
GS 66
  GST M2 (yb2)
Rat, Purified Native
GS 24
  GST P1-1
Purified Recombinant
GS 70
  GST T1-1
Human Recombinant
GS 90
  GST T1-1
Mouse Recombinant
GS 02
  GST T1-1
Rat Recombinant
GS 38
  GST T2-2
Rat Recombinant
GS 39
  Glyoxalase I
Human Recombinant
GL 10
  Glyoxzlase II
Human Recombinant
GL 20