Isoprostane levels are widely used for assessment of oxidative stress. Our isoprostane ELISAs have been developed
and extensively validated to provide the optimal quantification of in vivo isoprostane production. We also offer a low
cost, easy-to-assay kit (FR 22) that quantifies both 4-HNE or Malondialdehyde, both of which are established biomarkers
for oxidative stress.

Oxidative protein modifications are implicated in the pathology of multiple diseases and may be involved in cellular redox
signaling. Formation of protein carbony1 groups is orders of magnitude greater than other oxidative protein modifications,
so our regents and assay kits provide the best sensitivity for this key biomarker of protein oxidation. Our Nitrotyrosine (NT)
ELISA kit measures NT in biological specimens without interference from free NT. The purified anti-NT is useful for WB and
IHC. Initial products of ROS and protein reactions have a short half-life, making identification difficult. Immuno-spin Trapping
with DMPO followed by detection with anti-DNP is invaluable for detecting proteins following radical attack.

Given the multiplicity of antioxidant pathways it is important to be able to quantitatively measure the total antioxidant capacity or antioxidant power with biological specimens.

Glutathione is a naturally occurring tripeptide that is crucial to a variety of life processes, including the removal of hydroperoxides and free radicals.

Regulatory enzymes are vital to the maintenance of oxidant status. The assay kits listed below permit rapid and reliable quantification of key enzymes involved in redox regulation.

We offer reagents and assay kits for the quantitative detection of cellular responses to stress, ranging from transcriptional activation to cytotoxicity. Our chemiluminescent assay for NF-kB activation is the most sensitive kit available and the only one that incorporates a recombinant standard for precise quantification.