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  Cyclooxygenase(COX) adds molecular oxygen to arachidonic acids to form PGG2 and then PGH2. Inhibition of the cyclo- oxygenase activity of COX is responsible for the anti-inflammatory activity of aspirin and other non-steroidal anti-inflammatory drugs. COX-1 and COX-2 have been extensively characterized and the transcription of both COX-1 and COX-2 genes is highly regulated. Given issues regarding toxicity of both COX-1 and COX-2 inhibitors, there is renewed interest in down-stream enzymes that catalyze production of specific prostanoids. Microsomal PGE synthase (mPGES) produces PGE2, a major mediator of inflammation. The co-localization of mPGES with COX-2 and their coordinated upregulation in several tissues strongly supports an intergral role for this enzyme in inflammatory reactions. PGD2 is another major prostaglandin formed in a variety of tissues and involved in many physiological events. Two types of PGD synthase have been reported. One is glutathione (GSH) requiring PGD synthase and the other is GSH-independent PGD synthase.
Products
Quantity/Species
Catalog #
COX-1 Purified Ovine Multiple Quantities
NP 01
Recombinant Human COX-1 Multiple Quantities
RP 01
Antibodies Specific for COX-1 Poly & Monoclonal
Several
COX-1 Promoter Construct 1 Vial
PG 07
Recombinant Human COX-2 Multiple Quantities
RP 02
Antibodies Specific for COX-2 Poly & Monoclonal
Several
COX-2 Promoter Construct 1 Val
PG 09
Anti-PGD Synthase Polyclonal
PD 01
Anti-Prostacyclin Synthase Monoclonal
PG 23
Prostaglandin E2 ELISA Kit (Polyclonal) 96 Assays
EA 02
Prostaglandin E2 ELISA Kit (Monoclonal) 96 Assays
EA 03
Prostaglandin F ELISA Kit 96 Assays
EA 05
15-Keto dihydro-PGF F ELISA Kit 96 Assays
EA 20
6-Keto-PG ELISA Kit 96 Assays
EA 08
11β-Prostaglandin F ELISA Kit 96 Assays
EA 11
Thromboxane E2 ELISA Kit 96 Assays
EA 25
11-Dehydro-thromboxane E2 ELISA Kit 96 Assays
EA 30
Lipoxygenases (LOX) are non-heme iron-containing dioxygenases. Arachidonic acid is the most important substrate for most mammalian lipoxygenases, and these enzymes are designated accord-ing to the specific positional oxygenation of arachidonic acid. 5-,8-,12-, and 15-oxygenated deriva-tives of arachidonic acid have all been demonstrated to produce a wide range of physiologically active metabolities. Lipoxygenases catalyze the committed steps in pathways leading to a wide variety of bioactive lipids including hydroxyl- and hydroperoxy-derivatives, as well as leukotrienes.
Products
Quantity/Species
Catalog #
Anti-8-Lipoxygenase Polyclonal
LX 08
12-Lipoxygenase Multiple Quantities
LX 12PS
Anti-15-Lipoxygenase Form 2 Polyclonal
LX 25
Leukotriene B2 ELISA Kit 96 Assays
EA 35
Leukotriene C4 ELISA Kit 96 Assays
EA 38
Leukotriene C4 / D4 / E4 ELISA Kit 96 Assays
EA 39
Lipoxin A4 ELISA Kit 96 Assays
EA 45
15-Epi-Lipoxin A4 ELISA Kit 96 Assays
EA 46
13(S)-HODE ELISA Kit 96 Assays
EA 81
9(+/-)-HODE ELISA Kit 96 Assays
EA 80
  The central role of eicosanoids in inflammation and in the etiology of many diseases is now widely recognized. In addition to the COX and LOX pathways, certain cytochromes P450 produce potent epoxy and hydroxyl derivatives of arachidonic acid. Among these, 20-HETE has been extensively studied based on its role in hypertension. Phospholipase A2 (PLA2) enzymes liberate membrane bound arachidonic acid required for all of these pathways. To support ongoing research into the enzymes of eicosanoid metabolism, we also provide ram seminal vesicles (the original source from which purified COX-1 was obtained, and a rich source for many eicosanoid-metabolizing enzymes) as well as seminal vesicle microsomes. We also continue to collaborate with scientists world-wide to develop new assays for eicosanoids and new applications. For example, although PGF2alpha is historically associated with reproductive physiology, Samar Basu and others have clearly demonstrated that 15 keto-dyhydro-PGF2alpha is an excellent biomarker for inflammation.
Products
Quantity/Species
Catalog #
Anti-Mopuse PLA2 Polyclonal
PL 05
20-HETE ELISA Kit 96 Assays
HT 20
Ram Seminal Vesicles Various Quantities
V 01
Ram Seminal Vesicles Microsomes Various Quantities
V 02
Histamine ELISA Kit 96 Assays
EA 31