| Ubiquitin and Ubiquitin-like Proteins |
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| Welchman, R.L., Gordon, C. and Mayer, R.J. |
| Ubiquitin and ubiquitin-like proteins are involved in cellular regulatory activities to an extent that rivals protein phosphorylation. Our poster summarizes current knowledge of these important post-translational modifications and supplements a review article. ( Poster 1 ) |
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| Pharmacological Modulators of Peripheral Sensitization |
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| Michael R. Vasko and Grant D. Nicol, Indiana University |
| Peripheral sensitization is defined here as a reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. Inhibitory and excitatory modulators of peripheral sensitization are reviewed in this poster. ( Poster 2 ) |
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| G-protein-coupled Receptors & Signalling Networks |
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| Maria Julia Marinissen, Universidad Autonoma de Madrid
J. Silvio Gutkind, National Institutes of Health |
| G-protein-coupled receptors (GPCRs) constitute the largest family of cell-surface molecules involved in signal transmission. The poster summaries the intricate network of intracellular signalling pathways involved in their function.( Poster 3 ) |
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| Regulation of Vascular Reactivity by G-protein-coupled Receptors |
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| Janet J. Maguire and Anthony P. Davenport, University of Cambridge |
| Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researches. This poster highlights the key GPCRs regulating vascular reactivity.( Poster 4 ) |
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| Gut Hormones and the Regulation of Appetite |
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| Victoria J. Taylor, Preeti H. Jethwa, Caroline J. Small and Stephen R. Bloom, Imperial College London |
| The gastrointestinal tract is the largest endocrine gland in the human body, secreting hormones that affect digestion, appetite and energy expenditure. Neuropeptide modulators and gut hormones that influence appetite are reviewed in this poster.( Poster 5 ) |
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| The GABA Receptors |
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| Norman Bowery, University of Birmingham Paul Whiting and Keith Wafford, Merck Sharpe and Dohme Research Laboratories |
| GABA is the most abundant inhibitory neurotransmitter in the brain. This poster provides an overview of GABA receptor structure, function and ligand binding sites.( Poster 6 ) |
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| Pharmacological Modulators of Peripheral Sensitization |
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| Michael R. Vasko and Grant D. Nicol, Indiana University |
| Peripheral sensitization is defined here as a reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. Inhibitory and excitatory modulators of peripheral sensitization are reviewed in this poster.( Poster 7 ) |
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| Calcium Imbalance and Neuroprotective Targets in Cerebral Ischemia and Brain Injury |
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| Elaine F. Besancon, Suzhen Guo, Josephine Lok and Eng H. Lo, Harvard Medical School Michael Tymianshi, University of Toronto |
| Peripheral sensitization is defined here as a reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. Inhibitory and excitatory modulators of peripheral sensitization are reviewed in this poster.( Poster 8 ) |
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| Seven Transmembrane Receptor Signaling |
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| Terry Kenakin, GlaxoSmithKline Research and Development
Robert Lefkowitz and Jonathan Violin, Duke University Medical Center Michel Bouvier and Genevieve Oligny-Longpre, Universite de Montreal |
| Seven-transmembrane (7-TM)-receptors are now recognised as complex processors of information that can bind to molecules and cytosolic interactants on the cell membrane. The 7-TM poster highlights the multiple behaviours of 7-TMs including G-protein-dependent and -independent signalling as well as the concept of collateral efficacy.( Poster 9 ) |
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