Adrenocorticotropic hormone (ACTH)

    Adrenocorticotropic hormone (ACTH), also known as corticotropin, is a polypeptide tropic hormone produced and secreted by the anterior pituitary gland. It is an important component of the hypothalamic-pituitary-adrenal axis and is often produced in response to biological stress (along with its precursor corticotropin-releasing hormone from the hypothalamus).
    Its principal effects are increased production and release of corticosteroids. Primary adrenal insufficiency, also called Addison's disease, occurs when adrenal gland production of cortisol is chronically deficient, resulting in chronically elevated ACTH levels; when a pituitary tumor is the cause of elevated ACTH (from the anterior pituitary) this is known as Cushing's Disease and the constellation of signs and symptoms of the excess cortisol (hypercortisolism) is known as Cushing's syndrome. A deficiency of ACTH is a cause of secondary adrenal insufficiency. ACTH is also related to the circadian rhythm in many organisms.
    ACTH stimulates secretion of glucocorticoid steroid hormones from adrenal cortex cells, especially in the zona fasciculata of the adrenal glands. ACTH acts by binding to cell surface ACTH receptors, which are located primarily on adrenocortical cells of the adrenal cortex. The ACTH receptor is a seven-membrane-spanning G protein-coupled receptor. Upon ligand binding, the receptor undergoes conformation changes that stimulate the enzyme adenylyl cyclase, which leads to an increase in intracellular cAMP and subsequent activation of protein kinase A.
    ACTH influences steroid hormone secretion by both rapid short-term mechanisms that take place within minutes and slower long-term actions. The rapid actions of ACTH include stimulation of cholesterol delivery to the mitochondria where the P450scc enzyme is located. P450scc catalyzes the first step of steroidogenesis that is cleavage of the side-chain of cholesterol. ACTH also stimulates lipoprotein uptake into cortical cells. This increases the bio-availability of cholesterol in the cells of the adrenal cortex.
    The long term actions of ACTH include stimulation of the transcription of the genes coding for steroidogenic enzymes, especially P450scc, steroid 11β-hydroxylase, and their associated electron transfer proteins. This effect is observed over several hours.
    In addition to steroidogenic enzymes, ACTH also enhances transcription of mitochondrial genes that encode for subunits of mitochondrial oxidative phosphorylation systems. These actions are probably necessary to supply the enhanced energy needs of adrenocortical cells stimulated by ACTH.
 

Adrenocorticotropic hormone

     
제 품 명 단위 Catalog 제조회사
  (D-Lys16)-ACTH (1-24) (human, bovine, rat) H-4996.0800 0.5 mg Bachem
  (D-Lys16)-ACTH (1-24) (human, bovine, rat) H-4996.1000 1 mg Bachem
  (D-Lys16)-ACTH (1-24) (human, bovine, mouse, ovine, porcine,
    rabbit, rat)
10-1-13B 1 mg APC
  (D-Lys16)-ACTH (1-24) (human, bovine, mouse, ovine, porcine,
    rabbit, rat)
10-1-13A 0.5 mg APC
  (D-Ser1)-ACTH (1-24) (human, bovine, rat) H-4718.0800 0.5 mg Bachem
  (D-Ser1)-ACTH (1-24) (human, bovine, rat) H-4718.1000 1 mg Bachem
  (Des-Glu5)-ACTH (1-24) (human, bovine, rat) H-6756.0001 1 mg Bachem
  (Des-Glu5)-ACTH (1-24) (human, bovine, rat) H-6756.0005 5 mg Bachem
  (Des-His6)-ACTH (1-24) (human, bovine, rat) H-6754.0001 1 mg Bachem
  (Des-His6)-ACTH (1-24) (human, bovine, rat) H-6754.0005 5 mg Bachem
  (Des-Ser3)-ACTH (1-24) (human, bovine, rat) H-6742.0001 1 mg Bachem
  (Des-Ser3)-ACTH (1-24) (human, bovine, rat) H-6742.0005 5 mg Bachem
  (DSer1)-ACTH (1-24) (human, bovine, mouse, ovine, porcine,
    rabbit, rat)
10-1-14B 1 mg APC
  (DSer1)-ACTH (1-24) (human, bovine, mouse, ovine, porcine,
    rabbit, rat)
10-1-14A 0.5 mg APC
  (Met(O)4,D-Lys8,Phe9)-ACTH (4-9) H-1175.0005 5 mg Bachem
  (Met(O)4,D-Lys8,Phe9)-ACTH(4-9) H-1175.0025 25 mg Bachem
  (p-Iodo-Phe7)-ACTH (4-10) 10-1-22B 5 mg APC
  (p-Iodo-Phe7)-ACTH (4-10) 10-1-22A 1 mg APC
  (p-Iodo-Phe7)-ACTH (4-10) H-2784.0005 5 mg Bachem
  (p-Iodo-Phe7)-ACTH (4-10) H-2784.0025 25 mg Bachem
  (Phe2,Nle4)-ACTH (1-24) (human, bovine, rat) H-6080.0500 0.5 mg Bachem
  (Phe2,Nle4)-ACTH (1-24) (human, bovine, rat) H-6080.1000 1 mg Bachem
  (Tyr15)-ACTH (7-15) 10-1-27B 5 mg APC
  (Tyr15)-ACTH (7-15) 10-1-27A 1 mg APC
  (Tyr15)-ACTH (7-15) H-1200.0005 5 mg Bachem
  (Tyr15)-ACTH (7-15) H-1200.0025 25 mg Bachem
  Acetyl-ACTH (1-14) 10-1-12B 5 mg APC
  Acetyl-ACTH (1-14) 10-1-12A 1 mg APC
  Acetyl-ACTH (1-14) H-1085.0001 1 mg Bachem
  Acetyl-ACTH (1-14) H-1085.0005 5 mg Bachem
  Acetyl-ACTH (1-17) H-1090.0001 1 mg Bachem
  Acetyl-ACTH (1-17) H-1090.0005 5 mg Bachem
  Acetyl-ACTH (2-24) (human, bovine, rat) H-6746.0001 1 mg Bachem
  Acetyl-ACTH (2-24) (human, bovine, rat) H-6746.0005 5 mg Bachem
  Acetyl-ACTH (3-24) (human, bovine, rat) H-6744.0001 1 mg Bachem
  Acetyl-ACTH (3-24) (human, bovine, rat) H-6744.0005 5 mg Bachem
  Acetyl-ACTH (4-24) (human, bovine, rat) H-6748.0001 1 mg Bachem
  Acetyl-ACTH (4-24) (human, bovine, rat) H-6748.0005 5 mg Bachem
  Acetyl-ACTH (7-24) (human, bovine, rat) H-6752.0001 1 mg Bachem
  Acetyl-ACTH (7-24) (human, bovine, rat) H-6752.0005 5 mg Bachem
  ACTH (1-10) H-1130.0005 5 mg Bachem
  ACTH (1-10) H-1130.0025 25 mg Bachem
  ACTH (1-10) (human) 10-1-34B 5 mg APC
  ACTH (1-10)(human) 10-1-34A 1 mg APC
  ACTH (1-13) H-1135.0001 1 mg Bachem
  ACTH (1-13) H-1135.0005 5 mg Bachem
  ACTH (1-13) (human) 10-1-28B 1 mg APC
  ACTH (1-13) (human) 10-1-28A 0.5 mg APC
  ACTH (1-14) 10-1-29B 5 mg APC
  ACTH (1-14) 10-1-29A 1 mg APC
  ACTH (1-14) H-1140.0001 1 mg Bachem
  ACTH (1-14) H-1140.0005 5 mg Bachem
  ACTH (1-16) H-6050.0001 1 mg Bachem
  ACTH (1-16) H-6050.0005 5 mg Bachem
  ACTH (1-16) (human) 10-1-26B 1 mg APC
  ACTH (1-16)(human) 10-1-26A 0.5 mg APC
  ACTH (1-17) H-1145.0001 1 mg Bachem
  ACTH (1-17) H-1145.0005 5 mg Bachem
  ACTH (1-17) (human) 10-1-58B 1 mg APC
  ACTH (1-17) (human) 10-1-58A 0.5 mg APC
  ACTH (1-24) (human, bovine, rat) H-1150.0001 1 mg Bachem
  ACTH (1-24) (human, bovine, rat) H-1150.0005 5 mg Bachem
  ACTH (1-24) (human) 10-1-21B 1 mg APC
  ACTH (1-24) (human) 10-1-21A 0.5 mg APC
  ACTH (1-39) (guinea pig) H-2894.0500 0.5 mg Bachem
  ACTH (1-39) (guinea pig) H-2894.1000 1 mg Bachem
  ACTH (1-39) (human) H-1160.0500 0.5 mg Bachem
  ACTH (1-39) (human) H-1160.1000 1 mg Bachem
  ACTH (1-39) (mouse, rat) H-4998.0500 0.5 mg Bachem
  ACTH (1-39) (mouse, rat) H-4998.1000 1 mg Bachem
  ACTH (1-39) (guinea pig) 10-1-17B 1 mg APC
  ACTH (1-39) (guinea pig) 10-1-17A 0.5 mg APC
  ACTH (1-39) (human) 10-1-10B 1 mg APC
  ACTH (1-39) (human) 10-1-10A 0.5 mg APC
  ACTH (1-39) (rat) 10-1-15B 1 mg APC
  ACTH (1-39) (rat) 10-1-15A 0.5 mg APC
  ACTH (1-4) H-1125.0005 5 mg Bachem
  ACTH (1-4) H-1125.0025 25 mg Bachem
  ACTH (11-24) 10-1-31B 5 mg APC
  ACTH (11-24) 10-1-31A 1 mg APC
  ACTH (11-24) H-1210.0005 5 mg Bachem
  ACTH (11-24) H-1210.0025 25 mg Bachem
  ACTH (12-39) (rat) 10-1-16B 1 mg APC
  ACTH (12-39) (rat) 10-1-16A 0.5 mg APC
  ACTH (18-39) (human) H-1215.0001 1 mg Bachem
  ACTH (18-39) (human) H-1215.0005 5 mg Bachem
  ACTH (18-39) (human) 10-1-32B 1 mg APC
  ACTH (18-39) (human) 10-1-32A 0.5 mg APC
  ACTH (2-24) (human, bovine, rat) H-6738.0001 1 mg Bachem
  ACTH (2-24) (human, bovine, rat) H-6738.0005 5 mg Bachem
  ACTH (22-39) 10-1-35 1 mg APC
  ACTH (22-39) H-2898.0001 1 mg Bachem
  ACTH (22-39) H-2898.0005 5 mg Bachem
  ACTH (3-24) (human, bovine, rat) H-4716.0001 1 mg Bachem
  ACTH (3-24) (human, bovine, rat) H-4716.0005 5 mg Bachem
  ACTH (34-39) 10-1-38B 5 mg APC
  ACTH (34-39) 10-1-38A 1 mg APC
  ACTH (34-39) H-1220.0005 5 mg Bachem
  ACTH (34-39) H-1220.0025 25 mg Bachem
  ACTH (4-10) H-1180.0005 5 mg Bachem
  ACTH (4-10) H-1180.0025 25 mg Bachem
  ACTH (4-10) (human) 10-1-37B 5 mg APC
  ACTH (4-10) (human) 10-1-37A 1 mg APC
  ACTH (4-11) H-1190.0005 5 mg Bachem
  ACTH (4-11) H-1190.0025 25 mg Bachem
  ACTH (4-11) (human) 10-1-40B 5 mg APC
  ACTH (4-11)(human) 10-1-40A 1 mg APC
  ACTH (4-9) 10-1-19B 5 mg APC
  ACTH (4-9) 10-1-19A 1 mg APC
  ACTH (4-9) H-1165.0005 5 mg Bachem
  ACTH (4-9) H-1165.0025 25 mg Bachem
  ACTH (5-10) 10-1-24B 5 mg APC
  ACTH (5-10) 10-1-24A 1 mg APC
  ACTH (5-10) H-1195.0025 25 mg Bachem
  ACTH (5-10) H-1195.0100 100 mg Bachem
  ACTH (6-24) (human) 10-1-55B 1 mg APC
  ACTH (6-24) (human) 10-1-55A 0.5 mg APC
  ACTH (7-38) (human) H-1205.0500 0.5 mg Bachem
  ACTH (7-38) (human) H-1205.1000 1 mg Bachem
  ACTH (7-38) (human) 10-1-30B 1 mg APC
  ACTH (7-38) (human) 10-1-30A 0.5 mg APC
  Biotin-ACTH (1-39)(human) 10-1-11B 1 mg APC
  Biotin-ACTH (1-39) (human) 10-1-11A 0.5 mg APC
  Endo-4a-Glu-ACTH (1-24) (human, bovine, rat) H-6758.0001 1 mg Bachem
  Endo-4a-Glu-ACTH (1-24) (human, bovine, rat) H-6758.0005 5 mg Bachem
  N-Acetyl, ACTH (1-17) (human) 10-1-59B 1 mg APC
  N-Acetyl, ACTH (1-17) (human) 10-1-59A 0.5 mg APC
  Tyr-ACTH (4-10) 10-1-23B 5 mg APC
  Tyr-ACTH (4-10) 10-1-23A 1 mg APC
  Tyr-ACTH (4-10) H-1185.0005 5 mg Bachem
  Tyr-ACTH (4-10) H-1185.0025 25 mg Bachem
  Tyr-ACTH (4-9) 10-1-20B 5 mg APC
  Tyr-ACTH (4-9) 10-1-20A 1 mg APC
  Tyr-ACTH (4-9) H-1170.0005 5 mg Bachem
  Tyr-ACTH (4-9) H-1170.0025 25 mg Bachem
  [Met(O)4,DLys8,Phe9] ACTH (4-9) (human) 10-1-45B 5 mg APC
  [Met(O)4,DLys8,Phe9] ACTH (4-9) (human) 10-1-45A 1 mg APC
BachemUSA, CE-marked
 

 ACTH Assay Kit (Bachem Products)

   
제 품 명 단위 Catalog
  ACTH (1-24) (human, bovine, rat) - Diluted Antiserum for RIA, Host: Rabbit 500 tests T-4121.0500
  ACTH (1-24) (human, bovine, rat) - EIA Kit, Host: Rabbit, High Sensitivity 1 kit S-1185.0001
  ACTH (1-24) (human, bovine, rat) - Immunofluorescence Kit, Host: Rabbit 1 kit S-3152.0001
  ACTH (1-24) (human, bovine, rat) - Purified Antiserum - IgG, Host: Rabbit 400 ug T-4122.0400
  ACTH (1-24) (human, bovine, rat) - RIA Kit, Host: Rabbit 1 kit S-2048.0001
  ACTH (1-24) (human, bovine, rat) - Undiluted Antiserum for IHC, Host: Rabbit 50 ul T-4123.0050
  ACTH (1-39) (human) - Diluted Antiserum for RIA, Host: Guinea Pig 500 tests T-5023.0500
  ACTH (1-39) (human) - Diluted Antiserum for RIA, Host: Rabbit 500 tests T-4117.0500
  ACTH (1-39) (human) - EIA Kit (H - sr, pl), Host: Rabbit, Extraction-free 1 kit S-1376.0001
  ACTH (1-39) (human) - EIA Kit (R - sr, pl), Host: Rabbit, Extraction-free 1 kit S-1377.0001
  ACTH (1-39) (human) - EIA Kit, Host: Rabbit, High Sensitivity 1 kit S-1184.0001
  ACTH (1-39) (human) - Immunofluorescence Kit, Host: Guinea Pig 1 kit S-3029.0001
  ACTH (1-39) (human) - Immunofluorescence Kit, Host: Rabbit 1 kit S-3030.0001
  ACTH (1-39) (human) - Purified Antiserum - IgG, Host: Rabbit 400 ug T-4118.0400
  ACTH (1-39) (human) - RIA Kit, Host: Rabbit 1 kit S-2204.0001
  ACTH (1-39) (human) - Undiluted Antiserum for IHC, Host: Guinea Pig 50 ul T-5024.0050
  ACTH (1-39) (human) - Undiluted Antiserum for IHC, Host: Rabbit 50 ul T-4119.0050
  ACTH (1-39) (mouse, rat) - Diluted Antiserum for RIA, Host: Rabbit 500 tests T-4000.0500
  ACTH (1-39) (mouse, rat) - EIA Kit (H - sr, pl), Host: Rabbit, Extraction-free 1 kit S-1378.0001
  ACTH (1-39) (mouse, rat) - EIA Kit (M - sr, pl), Host: Rabbit, Extraction-free 1 kit S-1467.0001
  ACTH (1-39) (mouse, rat) - EIA Kit (R - sr, pl), Host: Rabbit, Extraction-free 1 kit S-1379.0001
  ACTH (1-39) (mouse, rat) - EIA Kit, Host: Rabbit, High Sensitivity 1 kit S-1130.0001
  ACTH (1-39) (mouse, rat) - Immunofluorescence Kit, Host: Rabbit 1 kit S-3000.0001
  ACTH (1-39) (mouse, rat) - Purified Antiserum - IgG, Host: Rabbit 400 ug T-4001.0400
  ACTH (1-39) (mouse, rat) - RIA Kit (H - sr, pl), Host: Rabbit, Extraction-free 1 kit S-2010.0001
  ACTH (1-39) (mouse, rat) - RIA Kit (R - sr, pl), Host: Rabbit, Extraction-free 1 kit S-2093.0001
  ACTH (1-39) (mouse, rat) - RIA Kit, Host: Rabbit 1 kit S-2036.0001
  ACTH (1-39) (mouse, rat) - Immunofluorescence Kit, Host: Rabbit 1 kit S-3000.0001
  ACTH (1-39) (mouse, rat) - Purified Antiserum - IgG, Host: Rabbit 400 ug T-4001.0400
  ACTH (1-39) (mouse, rat) - RIA Kit (H - sr, pl), Host: Rabbit, Extraction-free 1 kit S-2010.0001
  ACTH (1-39) (mouse, rat) - RIA Kit (R - sr, pl), Host: Rabbit, Extraction-free 1 kit S-2093.0001
  ACTH (1-39) (mouse, rat) - RIA Kit, Host: Rabbit 1 kit S-2036.0001
  ACTH (1-39) (mouse, rat) - Undiluted Antiserum for IHC, Host: Rabbit 50 ul T-4002.0050
  ACTH (18-39) (human) - Diluted Antiserum for RIA, Host: Rabbit 500 tests T-4125.0500
  ACTH (18-39) (human) - Immunofluorescence Kit, Host: Rabbit 1 kit S-3031.0001
  ACTH (18-39) (human) - Purified Antiserum - IgG, Host: Rabbit 400 ug T-4126.0400
  ACTH (18-39) (human) - RIA Kit, Host: Rabbit 1 kit S-2049.0001
  ACTH (18-39) (human) - Undiluted Antiserum for IHC Host: Rabbit 50 ul T-4127.0050