PDE- resistant PKG Activators

  • 8- Bromo- β -phenyl- 1, N²- ethenoguanosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-8-Br-PET-cGMPS )
  • 8- Bromoguanosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-8-Br-cGMPS )
  • 8- (4- Chlorophenylthio)- ß- phenyl- 1, N²- ethenoguanosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-8-pCPT-PET-cGMPS )
  • 8- (4- Chlorophenylthio)guanosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-8-pCPT-cGMPS )
  • Guanosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-cGMPS )
  • 8- Nitroguanosine- 3', 5'- cyclic monophosphate
     


  • 8- Bromo- β -phenyl- 1, N²- ethenoguanosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer
       ( Sp-8-Br-PET-cGMPS )
       Membrane-permeant inhibitor of the retinal type cGMP-gated ion channel (cGMP antagonist) but activator of cyclic GMP-dependent
       protein kinase I α and I ß (cGMP agonist).
       Butt et. al., Br. J. Pharmacol., 116, 3110 - 3116 (1995).
    P 008 5 uM/ ~2.8 mg, 5 x 5 uM CAS No.: [172806-21-2]

    8- Bromoguanosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-8-Br-cGMPS )
       Unspecific activator of both protein kinase G I α and protein kinase A. Resistant against cyclic nucleotide phosphodiesterases.
       Flaadt et al., J. Cell Sci., 105, 255 - 261 (1993).
    B 006 10 uM/ ~4.6 mg, 5 x 10 uM CAS No.: [153660-03-8]

    8- (4- Chlorophenylthio)- ß- phenyl- 1, N²- ethenoguanosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer
       ( Sp-8-pCPT-PET-cGMPS )
       Membrane-permeant activator of cyclic GMP-dependent protein kinase, but most probably inhibitor of the retinal type cGMP-gated ion
       channel, thus suitable for distinction between kinase and ion channel mediated effects.
       Prabhu, N.S.; Nucl. Acids Res., 25, 5119 - 5124 (1997)
    C 047 1 uM/ ~0.6 mg, 5 x 1 uM CAS No.: [pending]

    8- (4- Chlorophenylthio)guanosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-8-pCPT-cGMPS )
       Activator of protein kinase G type I α and type II.
       Butt et al., Eur. J. Pharmacol., 269, 265 - 268 (1994), Gamm et al., J. Biol. Chem., 270, 27380 - 27388 (1996).
    C 014 5 uM/ ~2.6 mg, 5 x 5 uM CAS No.: [160385-87-5]

    Guanosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-cGMPS )
       Metabolically resistant activator of cGMP-dependent protein kinases.
       Butt et al., FEBS Lett., 263, 47 - 50 (1990).
    G 017 5 uM/ ~1.9 mg, 5 x 5 uM CAS No.: [86562-10-9]

    8- Nitroguanosine- 3', 5'- cyclic monophosphate ( 8-NO2-cGMP )
       The nitrated derivative of cGMP, 8-NO2-cGMP, is considered to play an important role in NO-mediated signal transduction.
       Sawa et al., Nat. Chem. Biol., 3, 727 - 735 (2007).
    N 011   CAS No.: [pending]