Other PKA Activators

  • Adenosine- 1- N- oxid- 3', 5'- cyclic monophosphate
  • Adenosine- 3' ,5'- cyclic monophosphate ( cAMP ), free acid form
  • Adenosine- 3', 5'- cyclic monophosphate ( cAMP ), sodium salt
  • N6- (2- Aminoethyl)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-6-AE-cAMPS
  • 8- (6- Aminohexylamino)adenosine- 3', 5'- cyclic monophosphate ( 8-AHA-cAMP )
  • 2- Aza- 1, N6- ethenoadenosine- 3', 5'- cyclic monophosphate ( 2-Aza-ε-cAMP )
  • 8- Azido- 1, N6- ethenoadenosine- 3', 5'- cyclic monophosphate ( 8-N3-ε-cAMP )
  • 8- Azido- N6- (2- [DY-547]- aminoethyl)adenosine- 3', 5'- cyclic monophosphate ( 8-N3-6-[DY-547]-AE-cAMP )
  • 8- Azido- N6- (6- [biotinyl]aminoethyl)adenosine- 3', 5'- cyclic monophosphate ( 8-N3-6-[Biotin]-AE-cAMP )
  • 8- Azidoadenosine- 3', 5'- cyclic monophosphate ( 8-N3-cAMP )
  • N6- Benzoyladenosine- 3', 5'- cyclic monophosphate ( 6-Bnz-cAMP )
  • N6- Benzyladenosine- 3', 5'- cyclic monophosphate ( 6-Bn-cAMP )
  • 8- Benzylthioadenosine- 3', 5'- cyclic monophosphate ( 8-BT-cAMP )
  • 8- (2- [ Biotinyl]aminoethylthio)adenosine- 3', 5'- cyclic monophosphate ( 8-[Biotin]-AET-cAMP )
  • 2- (6- [ Biotinyl]aminohexylamino)adenosine- 3', 5'- cyclic monophosphate ( 2-[Biotin]-AHA-cAMP )
  • 6, 7- Bis(carboxymethoxy)coumarin- 4- yl)methyl- adenosine- 3', 5'- cyclic monophosphate ( BCMCM-caged cAMP )
  • [6, 7- Bis(carboxymethoxy)coumarin- 4- yl]methyl- 8- bromoadenosine- 3', 5'- cyclic monophosphate ( BCMCM-caged 8-Br-cAMP )
  • 8- Bromoadenosine- 3', 5'- cyclic monophosphate ( 8-Br-cAMP ), economy grade
  • 8- Bromoadenosine- 3', 5'- cyclic monophosphate ( 8-Br-cAMP ), fluorescence grade
  • 2- Chloro- 8- methylaminoadenosine- 3', 5'- cyclic monophosphate ( 2-Cl-8-MA-cAMP )
  • 2- Chloroadenosine- 3', 5'- cyclic monophosphate ( 2-Cl-cAMP )
  • 8- Chloroadenosine- 3', 5'- cyclic monophosphate ( 8-Cl-cAMP )
  • 8- (4- Chlorophenylthio)- N6- phenyladenosine- 3', 5'- cyclic monophosphate ( 8-CPT-6-Phe-cAMP )
  • 8- (4- Chlorophenylthio)adenosine- 3', 5'- cyclic monophosphate ( 8-CPT-cAMP ), economy grade
  • 8- (4- Chlorophenylthio)adenosine- 3', 5'- cyclic monophosphate ( 8-CPT-cAMP ), fluorescence grade
  • 6- Chloropurine riboside- 3', 5'- cyclic monophosphate ( 6-Cl-cPuMP )
  • 7- Deazaadenosine- 3', 5'- cyclic monophosphate ( 7-CH-cAMP )
  • N6, 2'- O- Dibutyryladenosine- 3', 5'- cyclic monophosphate ( DB-cAMP, Bucladesine ), economy grade
  • N6, 2'- O- Dibutyryladenosine- 3', 5'- cyclic monophosphate ( DB-cAMP, Bucladesine ), high purity grade
  • 5, 6- Dichlorobenzimidazole riboside- 3', 5'- cyclic monophosphate ( 5,6-DCl-cBIMP )
  • (7- Diethylaminocoumarin- 4- yl)methyladenosine- 3', 5'- cyclic monophosphate ( DEACM-caged cAMP )
  • 1, N6- Ethenoadenosine- 3', 5'- cyclic monophosphate ( ε-cAMP )
  • 8- (2- [ Fluoresceinyl]aminoethylthio)adenosine- 3', 5'- cyclic monophosphate ( 8-Fluo-cAMP )
  • 8- Hexylaminoadenosine- 3', 5'- cyclic monophosphate ( 8-HA-cAMP )
  • 8- Hydroxyadenosine- 3', 5'- cyclic monophosphate ( 8-OH-cAMP )
  • Inosine- 3', 5'- cyclic monophosphate ( cIMP )
  • 8- Methylaminoadenosine- 3', 5' cyclic monophosphate ( 8-MA-cAMP )
  • 8- (4- [N- Methylanthraniloyl]aminobutylamino)adenosine- 3', 5'- cyclic monophosphate ( 8-MABA-cAMP )
  • N6- (6- [N- Methylanthraniloyl]hexylamino)adenosine-3', 5'- cyclic monophosphate ( 6-MAH-cAMP )
  • N6- Mono- tert. butylcarbamoyladenosine- 3', 5'- cyclic monophosphate ( 6-MBC-cAMP )
  • N6- Monobutyryladenosine- 3', 5'- cyclic monophosphate ( 6-MB-cAMP )
  • 8- (2- [7- Nitro- 4- benzofurazanyl]aminoethylthio)adenosine- 3', 5'- cyclic monophosphate ( 8-NBD-cAMP )
  • 8- [ Pharos-450]- adenosine- 3', 5'- cyclic monophosphate ( 8-[φ-450]-cAMP )
  • 8- [ Pharos-575]- adenosine- 3', 5'- cyclic monophosphate ( 8-[φ-575]-cAMP )
  • N6- Phenyladenosine- 3', 5'- cyclic monophosphate ( 6-Phe-cAMP )
  • 8- Piperidinoadenosine- 3', 5'- cyclic monophosphate ( 8-PIP-cAMP )
     

  • Adenosine- 1- N- oxid- 3', 5'- cyclic monophosphate
       Polar cAMP analogue with modified N-1 moiety for receptor mapping studies.
       Jastorff in Cyclic Nucleotides and Therapeutic Perspectives, Cehovic & Robison (eds.), pp. 85 - 95; Pergamon Press, Oxford/New York 1979.
    A 023 10 uM/~1.8 mg, 5 x 5 uM CAS No.: [75912-25-3]

    Adenosine- 3' ,5'- cyclic monophosphate ( cAMP ), free acid form
       The second messenger cyclic AMP activates protein kinase A, cAMP-gated ion channels, HCN channels, the Epac receptor
       (cAMP-GEF), the CAP protein and some other target receptors.
       References
    A 001 H 500 mg/~1.5mM, 5 x 500 mg CAS No.: [60-92-4]

    Adenosine- 3', 5'- cyclic monophosphate ( cAMP ), sodium salt
       The second messenger cyclic AMP activates protein kinase A, cAMP-gated ion channels, HCN channels, the Epac receptor
       (cAMP-GEF), the CAP protein and some other target receptors.
       References
    A 001 500 uM/ ~176 mg, 5 x 500 uM CAS No.: [37839-81-9]

    N6- (2- Aminoethyl)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-6-AE-cAMPS )
       Phosphodiesterase-resistant ligand for affinity chromatography of cAMP and cGMP binding proteins and suitable for modification with
       fluorophores and other markers.
    A 092 5 uM/ ~1.9 mg, 5 x 5 uM CAS No.: [pending]

    8- (6- Aminohexylamino)adenosine- 3', 5'- cyclic monophosphate ( 8-AHA-cAMP )
       cyclic AMP functionalized for conjugation with markers and dyes or for immobilization
       Skalhegg et al., J. Biol. Chem., 267, 15707 - 15714 (1992). Herberg et al., J. Mol. Biol., 298, 329 - 339 (2000); Moll et al., J. Neural. Transm., 113, 1015 - 1032 (2006)
    A 011 10 uM/ ~4.4 mg, 5 x 10 uM CAS No.: [39824-30-1]

    2- Aza- 1, N6- ethenoadenosine- 3', 5'- cyclic monophosphate ( 2-Aza-ε-cAMP )
       cyclic AMP functionalized for conjugation with markers and dyes or for immobilization   (λexc 358 nm, λem 494 nm.)
       Tsou et al., Anal. Biochem., 60, 163 - 169 (1974); Kraemer et al., J. Mol. Biol., 306, 1167 - 1177 (2001).
    A 015 5 uM/ ~1.9 mg, 5 x 5 uM CAS No.: [50663-90-6]

    8- Azaadenosine- 3', 5'- cyclic monophosphate ( 8-Aza-cAMP )
       This compound is not a regular product, but is offered under Biolog's
      
    A 150   CAS No.: [67190-31-2]

    8- Azido- 1, N6- ethenoadenosine- 3', 5'- cyclic monophosphate ( 8-N3-ε-cAMP )
       Nonfluorescent cAMP analogue, that can be used for labelling of cAMP receptors.
       Keeler & Campbell, Biochem. Biophys. Res. Commun., 72, 575 - 80 (1976); Dreyfuss et al., Proc. Nat. Acad. Sci. USA, 75, 1199 - 1203 (1978).
    A 077 1 uM/ ~0.4 mg, 5 x 1 uM CAS No.: [60902-12-7]

    8- Azido- N6- (2- [DY-547]- aminoethyl)adenosine- 3', 5'- cyclic monophosphate ( 8-N3-6-[DY-547]-AE-cAMP )
       8-N3-6-[DY547]-AE-cAMP is a light sensitive analogue for photoaffinity labelling. It can be immobilized within a cyclic AMP binding
       site by illumination with UV light.   (λexc 557 nm, λem 574 nm.)
    A 100 0.1 uM/ ~0.1 mg, 5 x 0.1 uM CAS No.: [pending]

    8- Azido- N6- (6- [biotinyl]aminoethyl)adenosine- 3', 5'- cyclic monophosphate ( 8-N3-6-[Biotin]-AE-cAMP )
       Analogue for photoaffinity labelling of cAMP binding proteins which can be immobilized by UV light. The biotin label is connected to
       the 6-position of cyclic AMP via a 15 atom spacer.
    A 127 0.1 uM/ ~80 ug, 5 x 0.1 uM CAS No.: [pending]

    8- Azidoadenosine- 3', 5'- cyclic monophosphate ( 8-N3-cAMP )
       Analogue for photoaffinity labelling of cAMP binding proteins.
    A 014 10 uM/ ~3.9 mg, 5 x 10 uM CAS No.: [31966-52-6]

    N6- Benzoyladenosine- 3', 5'- cyclic monophosphate ( 6-Bnz-cAMP )
       Membrane-permeant, site-selective PKA agonist
       Christensen et al., J. Biol. Chem., 278, 35394 - 35402 (2003); Bos, Trends Biochem. Sci., 31, 680 - 686 (2006).
    B 009 10 uM/ ~4.6 mg, 5 x 10 uM CAS No.: [30275-80-0]

    N6- Benzoyladenosine- 3', 5'- cyclic monophosphate, acetoxymethyl ester ( 6-Bnz-cAMP-AM )
       Metabolically activatable, highly membrane-permeant PKA agonist.
      
    B 079 1 umol / ~0.5 mg, 5 x 1 umol  

    N6- Benzyladenosine- 3', 5'- cyclic monophosphate ( 6-Bn-cAMP )
       Site selective activator of cAMP-dependent protein kinase which does not activate Epac.
       Pepe et al., Cancer Res., 51, 6263 - 6267 (1991).
    B 008 10 uM/ ~4.4 mg, 5 x 10 uM CAS No.: [32115-08-5]

    8- Benzylthioadenosine- 3', 5'- cyclic monophosphate ( 8-BT-cAMP )
       Site selective activator of cAMP-dependent protein kinase. Increased hydrolytical stability against PDE and considerably higher
       membrane permeability compared to cAMP.
       Eskin, J. Neurobiol., 13, 241 - 249 (1982).
    B 015 10 uM/ ~4.7 mg, 5 x 10 uM CAS No.: [50655-17-9]

    8- (2- [ Biotinyl]aminoethylthio)adenosine- 3', 5'- cyclic monophosphate ( 8-[Biotin]-AET-cAMP )
       The biotin label is connected to the 6-position of cyclic AMP via a 16 atom spacer.
    B 030 1 uM/ ~0.8 mg, 5 x 1 uM CAS No.: [pending]

    2- (6- [ Biotinyl]aminohexylamino)adenosine- 3', 5'- cyclic monophosphate ( 2-[Biotin]-AHA-cAMP )
       The biotin label is connected to the 2-position of cyclic AMP via a 19 atom spacer.
    B 041 1 uM/ ~0.8 mg, 5 x 1 uM CAS No.: [pending]

    6, 7- Bis(carboxymethoxy)coumarin- 4- yl)methyl- adenosine- 3', 5'- cyclic monophosphate ( BCMCM-caged cAMP )
       BCMCM-caged cAMP is an only weakly fluorescent, caged precursor of the second messenger cyclic AMP, which upon irradiation,
       releases both cAMP and a fluorescent coumarin analogue.
       Hagen et al., Angew. Chem. Int. Ed., 40, 1046 - 1048 (2001).
    B 016 0.1 uM/ ~68 ug, 5 x 0.1 uM CAS No.: [339291-51-9]

    6, 7- Bis(carboxymethoxy)coumarin- 4- yl]methyl- 8- bromoadenosine- 3', 5'- cyclic monophosphate
       ( BCMCM-caged 8-Br-cAMP )
       BCMCM-caged 8-Br-cAMP is an only weakly fluorescent, caged precursor of 8-bromo cyclic cAMP, which upon irradiation, releases
       both 8-Br-cAMP and a fluorescent coumarin analogue.
       Hagen et al., Angew. Chem. Int. Ed., 40, 1046 - 1048 (2001).
    B 018 0.1 uM/ ~76 ug, 5 x 0.1 uM CAS No.: [370091-64-8]

    8- Bromoadenosine- 3', 5'- cyclic monophosphate ( 8-Br-cAMP ), economy grade
       Activator of cAMP-dependent protein kinase and of Epac. Increased hydrolytical stability and membrane permeability compared to
       cAMP.
       Kroeber et al., J. Neurochem., 74, 2478 - 2489 (2000).
    B 007 E 50 mg/ ~116 uM, 5 x 50 mg CAS No.: [76939-46-3]

    8- Bromoadenosine- 3', 5'- cyclic monophosphate ( 8-Br-cAMP ), fluorescence grade
       Activator of cAMP-dependent protein kinase and of Epac. Increased hydrolytical stability and membrane permeability compared to
       cAMP.
       Kroeber et al., J. Neurochem., 74, 2478 - 2489 (2000).
    B 007 100 uM/ ~43 mg, 5 x 100 uM CAS No.: [76939-46-3]

    2- Chloro- 8- methylaminoadenosine- 3', 5'- cyclic monophosphate ( 2-Cl-8-MA-cAMP )
       Cyclic AMP analogue with high selectivity for site B I of PKA. Can be combined with AI- selective analogues for synergistic activation of
       PKA type I.
       Krakstad et al., J. Leukocyte Biol., 76, 641 - 647 (2004).
    C 080 5 uM/ ~2.1 mg, 5 x 5 uM CAS No.: [96990-16-8]

    2- Chloroadenosine- 3', 5'- cyclic monophosphate ( 2-Cl-cAMP )
       Site selective cyclic AMP analogue with high selectivity for the B sites of both protein kinase A type I and II.
       Hoffmann et al., Cell. Pharmacol., 3, 417 - 427 (1996).
    C 020 5 uM/ ~1.9 mg, 5 x 5 uM CAS No.: [39023-65-9]

    8- Chloroadenosine- 3', 5'- cyclic monophosphate ( 8-Cl-cAMP )
       Site selective cyclic AMP analogue with high selectivity for protein kinase A type I.
       Schwede et al., Pharmacol. Ther., 87, 199 ? 226 (2000).
    C 007 10 uM/ ~3.9 mg, 5 x 10 uM CAS No.: [41941-56-4]

    8- (4- Chlorophenylthio)- N6- phenyladenosine- 3', 5'- cyclic monophosphate ( 8-CPT-6-Phe-cAMP )
       Highly lipophilic site-selective activator of protein kinase A (cyclic AMP agonist).
       Miller et al., J. Med. Chem., 23, 242 - 251 (1980).
    C 043 5 uM/ ~2.8 mg, 5 x 5 uM CAS No.: [72549-36-1]

    8- (4- Chlorophenylthio)adenosine- 3', 5'- cyclic monophosphate ( 8-CPT-cAMP ), economy grade
       Lipophilic activator of both cAMP- and cGMP- dependent protein kinase and of Epac.
       Geiger et al.: Proc. Natl. Acad. Sci. USA, 89, 1031 - 1035 (1992). Murray et al.: Biochem. Pharmacol., 44, 2303 - 2306 (1992)
    C 010 E 50 mg/ ~102uM, 5 x 50 mg CAS No.: [93882-12-3]

    8- (4- Chlorophenylthio)adenosine- 3', 5'- cyclic monophosphate ( 8-CPT-cAMP ), fluorescence grade
       Lipophilic activator of both cAMP- and cGMP- dependent protein kinase and of Epac.
       Geiger et al.: Proc. Natl. Acad. Sci. USA, 89, 1031 - 1035 (1992). Murray et al.: Biochem. Pharmacol., 44, 2303 - 2306 (1992)
    C 010 100 uM/ ~49mg, 5 x 100 uM CAS No.: [93882-12-3]

    6- Chloropurine riboside- 3', 5'- cyclic monophosphate ( 6-Cl-cPuMP )
       Analogue of cyclic AMP showing better membrane permeability and higher stability against phosphodiesterases.
       Michal et al., Pharmacol. Res. Commun., 6, 203 - 252 (1974).
    C 002 5 uM/ ~1.9 mg, 5 x 5 uM CAS No.: [94200-58-5]

    7- Deazaadenosine- 3', 5'- cyclic monophosphate ( 7-CH-cAMP )
       Cyclic AMP analog with lacking purine N-7 nitrogen for receptor mapping studies.
       Ruchaud et al., Cell. Pharmacol., 2, 127 - 140 (1995).
    D 021 5 uM/ ~1.8 mg, 5 x 5 uM CAS No.: [16719-36-1]

    N6, 2'- O- Dibutyryladenosine- 3', 5'- cyclic monophosphate ( DB-cAMP, Bucladesine ), economy grade
       Membrane-permeant activator of protein kinase A (cyclic AMP agonist).
       Posternak et al., Methods Enzymol., 38, 399 (1974).
    D 009 E 50 mg/ ~102 uM, 5 x 50 mg CAS No.: [16980-89-5]

    N6, 2'- O- Dibutyryladenosine- 3', 5'- cyclic monophosphate ( DB-cAMP, Bucladesine ), high purity grade
       Membrane-permeant activator of protein kinase A (cyclic AMP agonist).
       Posternak et al., Methods Enzymol., 38, 399 (1974).
    D 009 100 uM/ ~49 mg, 5 x 100 uM CAS No.: [16980-89-5]

    5, 6- Dichlorobenzimidazole riboside- 3', 5'- cyclic monophosphate ( 5,6-DCl-cBIMP )
       Potent and lipophilic activator of protein kinase A, type I & II.
       Dostmann et al., J. Biol. Chem., 265, 10484 - 10491 (1990).
    D 011 10 uM/ ~4 mg, 5 x 10 uM CAS No.: [129693-10-3]

    (7- Diethylaminocoumarin- 4- yl)methyladenosine- 3', 5'- cyclic monophosphate ( DEACM-caged cAMP )
       DEACM-caged cAMP is an only weakly fluorescent, caged precursor of the second messenger cyclic AMP, which upon irradiation, releases both cAMP and a fluorescent coumarin analogue.
       Hagen et al., Angew. Chem. Int. Ed., 40, 1046 - 1048 (2001).
    D 042 0.1 uM/ ~58 ug, 5 x 0.1 uM CAS No.: [339291-37-1]

    1, N6- Ethenoadenosine- 3', 5'- cyclic monophosphate ( ε-cAMP )
       Fluorescent cAMP analogue; λexc 300 nm, λem 415 nm.
       Secrist et al., Biochemistry, 11, 3499 - 3506 (1972).
    E 001 10 uM/ ~3.8 mg, 5 x 10 uM CAS No.: [103213-51-0]

    8- (2- [ Fluoresceinyl]aminoethylthio)adenosine- 3', 5'- cyclic monophosphate ( 8-Fluo-cAMP )
       Fluorescent cAMP analogue; λexc 494 nm, λem 517 nm.
       Schwede et al., Biochemistry, 39, 8803 - 8812 (2000).
    F 002 1 uM/ ~0.8 mg, 5 x 1 uM CAS No.: [293296-57-8]

    8- Hexylaminoadenosine- 3', 5'- cyclic monophosphate ( 8-HA-cAMP )
       Site-selective analogue of cyclic AMP which prefers site B of PKA I. High membrane permeability and improved stability towards
       phosphodiesterases.
       Schwede et al., Biochemistry, 39, 8803 - 8812 (2000).
    F 006 5 uM/ ~2.3 mg, 5 x 5 uM CAS No.: [59212-44-1]

    8- Hydroxyadenosine- 3', 5'- cyclic monophosphate ( 8-OH-cAMP )
       Polar, membrane-impermeant analogue of cyclic AMP for the study of extracellular cAMP receptors. If applied by patch clamp
       techniques, 8-OH-cAMP should remain trapped inside the cell.
       Schwede et al., Biochemistry, 39, 8803 - 8812 (2000).
    H 003 5 uM/ ~1.8 mg, 5 x 5 uM CAS No.: [31356-95-3]

    Inosine- 3', 5'- cyclic monophosphate ( cIMP )
      
       Poteet-Smith et al., J. Biol. Chem., 272, 379 - 388 (1997).
    I 001 50 uM/ ~18 mg, 5 x 50 uM CAS No.: [41092-64-2]

    8- Methylaminoadenosine- 3', 5' cyclic monophosphate ( 8-MA-cAMP )
       Site selective cyclic AMP analogue with similar affinity to site B of both protein kinase A type I and II.
       Skalhegg et al., J. Biol. Chem., 267, 15707 - 15714 (1992).
    M 001 10 uM/ ~3.8 mg, 5 x 10 uM CAS No.: [33823-18-6]

    8- (4- [N- Methylanthraniloyl]aminobutylamino)adenosine- 3', 5'- cyclic monophosphate ( 8-MABA-cAMP )
       Fluorescent, membrane- permeant cyclic AMP analogue (λexc 352 nm, λem 436 nm).
       Kraemer et al., J. Mol. Biol., 306, 1167 - 1177 (2001).
    M 016 5 uM/ ~2.9 mg, 5 x 5 uM CAS No.: [342029-95-2]

    N6- (6- [N- Methylanthraniloyl]hexylamino)adenosine-3', 5'- cyclic monophosphate ( 6-MAH-cAMP )
       Fluorescent, membrane- permeant cyclic AMP analogue. (λexc 333 nm, λem 437 nm).
       Kraemer et al., J. Mol. Biol., 306, 1167 - 1177 (2001); Moll et al., J. Neural. Transm., 113, 1015 - 1032 (2006). Theyssen, J. Mol. Biol., 263, 657 - 670 (1996).
    M 017 5 uM/ ~2.9 mg, 5 x 5 uM CAS No.: [723313-27-7]

    N6- Mono- tert. butylcarbamoyladenosine- 3', 5'- cyclic monophosphate ( 6-MBC-cAMP )
       Site selective activator of protein kinase A ( cyclic AMP agonist ) strongly preferring the A site of cAK II.
       Maronde et al., J. Pineal Res., 27, 170 - 182 (1999); Fricke et al., Endocrinology, 145, 4940 - 4947 (2004).
    M 012 5 uM/ ~2.3 mg, 5 x 5 uM CAS No.: [84433-46-5]

    N6- Monobutyryladenosine- 3', 5'- cyclic monophosphate ( 6-MB-cAMP )
       Membrane-permeant, site-selective activator of protein kinase A (cyclic AMP agonist). 6-MB-cAMP does not activate Epac and thus can
       be used as an Epac-negative control.
       Kopperud et al., FEBS Lett., 546, 121 - 126 (2003).
    M 003 50 uM/ ~21 mg, 5 x 50 uM CAS No.: [70253-67-7]

    8- (2- [7- Nitro- 4- benzofurazanyl]aminoethylthio)adenosine- 3', 5'- cyclic monophosphate ( 8-NBD-cAMP )
       Potent membrane-permeant fluorescent activator of cAMP-dependent protein kinase.   (λexc 471 nm, λem 536 nm.)
       Kraemer et al., J. Mol. Biol., 306, 1167 - 1177 (2001).
    N 002 1 uM/ ~0.6 mg, 5 x 1 uM CAS No.: [221905-51-7]

    8- [ Pharos-450]- adenosine- 3', 5'- cyclic monophosphate ( 8-[φ-450]-cAMP )
       Membrane-permeant, fluorescent analogue of cyclic AMP (λexc 450 nm, λem 534 nm.) by a spacer. a He/Cd laser. Due to its
       high lipophilicity and bright green fluorescence is especially suitable for studies with intact cells.
    P 024 0.1 uM/ ~72 ug, 5 x 0.1 uM CAS No.: [pending]

    8- [ Pharos-575]- adenosine- 3', 5'- cyclic monophosphate ( 8-[φ-575]-cAMP )
       Membrane-permeant, fluorescent analogue of cyclic AMP (λexc 577 nm, λem 605 nm.) by a spacer.Due to its high lipophilicity and bright
       red fluorescence 8-[φ-575]-cAMP is especially suitable for studies with intact cells.
       Moll et al., BMC Biochem., 9, 18 (2008).
    P 019 0.1 uM/ ~72 ug, 5 x 0.1 uM CAS No.: [pending]

    N6- Phenyladenosine- 3', 5'- cyclic monophosphate ( 6-Phe-cAMP )
       Potent site-selective activator of protein kinase A showing strong preference for site A of both isozymes.
       Kloss et al., Mol. Pharmacol., 65, 1440 - 1451 (2004).
    P 006 5 uM/ ~2.1 mg, 5 x 5 uM CAS No.: [34051-30-4]

    8- Piperidinoadenosine- 3', 5'- cyclic monophosphate ( 8-PIP-cAMP )
       Site selective cyclic AMP analogue with high selectivity for site A of protein kinase A type I and for site B of type II.
       Skalhegg et al., J. Biol. Chem., 267, 15707 - 15714 (1992).
    P 002 10 uM/ ~4.3 mg, 5 x 10 uM CAS No.: [31357-06-9]