PDE- resistant PKA Inhibitors

Adenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer ( Rp-cAMPS ), economy grade
   Membrane permeant and PDE-resistant inhibitor of PKA, Competitive inhibitor of protein kinase A type I and II (cyclic AMP antagonist).
A 002 T CAS No.: [151837-09-1] 5umol/~2.2mg (A002-05), 5x5 umol(A002-25)

Adenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer ( Rp-cAMPS ), high purity grade
   Membrane permeant and PDE-resistant inhibitor of PKA, CAS No.: [73208-40-9] , Competitive inhibitor of protein kinase A type I
   and II (cyclic AMP antagonist). Prefers type II of protein kinase A.
A 002 S CAS No.: [151837-09-1] 5umol/~2.2mg, 5x5 umol

8- (2- Aminoethylamino)adenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer, immobilized on agarose ( Rp-8-AEA-cAMPS-Agarose )
   Immobilized cAMP Antagonist, The metabolically stable protein kinase A inhibitor Rp-cAMPS (Cat. No. A 002) immobilized on agarose
   by an aminoethylamino spacer attached to position 8 of the ligand.
A 007   0.6 ml (A 007-06), 2.5 ml (A 007-25), 6 ml (A 007-60)

2'- O- (2- Aminoethylcarbamoyl)adenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer ( Rp-2'-AEC-cAMPS / Rp-2'-EDA-cAMPS )
   PDE-resistant Rp-cAMPS functionalized for immobilization or conjugation with markers and dyes.
A 119   5uM(A 119-05), 5x5uM(A 119-25)

8- (6- Aminohexylamino)adenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer ( Rp-8-AHA-cAMPS )
   The PKA inhibitor Rp-cAMPS functionalized for immobilization or conjugation with markers and dyes.
A 085 CAS No.: [214272-02-3] 5uM/~2.3mg, 5x5uM

8- (6- Aminohexylamino)adenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer, immobilized on agarose ( Rp-8-AHA-cAMPS-Agarose )
   cyclic AMP antagonist immobilized to agarose.
A 012   0.6 ml, 2.5 ml, 6 ml

2'- O- (6- Aminohexylcarbamoyl)adenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer ( Rp-2'-AHC-cAMPS )
   PDE-resistant Rp-cAMPS functionalized for immobilization or conjugation with markers and dyes.
A 120   5uM(A 120-05), 5x5uM(A 120-25)

8- Bromo- 2'- O- monobutyryladenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer ( Rp-8-Br-MB-cAMPS )
   Metabolically activatable form of the PKA inhibitor Rp-8-Br-cAMPS. CAS No.: [788807-32-9]
B 010 5uM/~2.6mg, 5x5uM

8- Bromoadenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer ( Rp-8-Br-cAMPS )
   Lipophilic analog of the cyclic AMP antagonist Rp-cAMPS, CAS No.: [129735-00-8] For other salt forms please inquire.
B 001 5uM/~2.2mg, 5x5uM

2- Chloroadenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer ( Rp-2-Cl-cAMPS )
   Analogue of the protein kinase A inhibitor Rp-cAMPS (Cat. No A 002) with increased lipophilicity and phosphodiesterase stability.
C 073 CAS No.: [124844-92-4] 5uM(C 073-05), 5x5uM(C 073-25)

8- Chloroadenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer ( Rp-8-Cl-cAMPS )
   Membrane-permeant analogue of the cyclic AMP antagonist Rp-cAMPS, For other salt forms please inquire.
C 003 CAS No.: [142754-27-6] 5uM/~2.0mg, 5x5uM

8- (4- Chlorophenylthio)adenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer ( Rp-8-CPT-cAMPS )
   Membrane-permeant and PDE-resistant PKA inhibitor, Considerably more lipophilic and membrane-permeant compared to
   Rp-8-Br-cAMPS (Cat. No. B 001) .
C 011 CAS No.: [129735-01-9] 5uM/~2.5mg, 5x5uM

8- Hydroxyadenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer ( Rp-8-OH-cAMPS )
   Polar, PDE-resistant analogue of the PKA inhibitor Rp-cAMPS, Resistant against mammalian cyclic nucleotide-dependent
   phosphodiesterases.
H 004 CAS No.: [755748-37-9] 1uM/~0.4mg, 5x1uM

2'- O- Monobutyryladenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer ( Rp-2'-O-MB-cAMPS )
   Metabolically activatable Form of the PKA inhibitor Rp-cAMPS, Lipophilic precursor of Rp-cAMPS (Cat. No. A 002), a competitive
   inhibitor of protein kinase A.
M 004 CAS No.: [152218-23-0] 5uM/~0.4mg, 5x5uM

8- Piperidinoadenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer ( Rp-8-PIP-cAMPS )
   Lipophilic site-selective analogue of the protein kinase A inhibitor Rp-cAMPS (Cat. No. A 002) with extremely high preference for site B
   of cAK type II.
P 004 CAS No.: [156816-36-3] 5uM/~2.3mg, 5x5uM