PDE- resistant PKA Activators

Adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-cAMPS ), economy grade
   PDE-resistant PKA agonist, Membrane permeability comparable to 8-Br-cAMP
A 003 T CAS No.: [93602-66-5] 10 uM/~4.5mg, 5 x 10 uM

Adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-cAMPS ), high purity grade
   PDE-resistant PKA agonist, Membrane permeability comparable to 8-Br-cAMP
A 003 S CAS No.: [71774-13-5] 10 uM/~3.7mg, 5 x 10uM

Adenosine- 3', 5'- monophosphorothioate acetoxymethyl ester, Sp- isomer ( Sp-cAMPS-AM )
   Membrane-permeant precursor of the PDE-resistant protein kinase A activator Sp-cAMPS. Metabolic bioactivation by esterases
   releases the active analogue, which is trapped inside the cell.
A 035   1 uM/~0.4mg, 5 x 1 uM

N6- (2- Aminoethyl)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-6-AE-cAMPS )
   PDE-resistant Sp-cAMPS functionalized for immobilization and conjugation with markers and dyes .
A 092 CAS No.: [pending] 5 uM/~1.9mg, 5 x 5 uM

N6- (2- Aminoethyl)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer, immobilized on agarose gel
   ( Sp-6-AE-cAMPS-Agarose )
   MPDE-resistant Sp-cAMPS immobilized on agarose.
A 109   0.6 ml, 2.5 ml, 6 ml

2- (2- Aminoethylamino)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-2-AEA-cAMPS )
   PDE-resistant Sp-cAMPS functionalized for immobilization or conjugation with markers and dyes .
A 093   5 umol / ~2 mg , 5 x 5 umol

8- (2- Aminoethylamino)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-8-AEA-cAMPS )
   PDE-resistant Sp-cAMPS functionalized for immobilization or conjugation with markers and dyes .
A 094 CAS No.: [221904-84-3] 5 umol / ~2 mg , 5 x 5 umol

2- (2- Aminoethylamino)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer, immobilized on agarose gel
   ( Sp-2-AEA-cAMPS-Agarose )
   PDE-resistant Sp-cAMPS immobilized to agarose. The gel can be used for affinity chromatography of various cyclic nucleotide-
   responsive proteins such as protein kinases, phosphodiesterases and others.
A 087   0.6 ml, 2.5 ml, 6 ml

8- (2- Aminoethylamino)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer, immobilized on agarose
   ( Sp-8-AEA-cAMPS-Agarose )
   Hydrolysis-resistant Sp-cAMPS immobilized on agarose.
A 008   0.6 ml, 2.5 ml, 6 ml

2'- O- (2- Aminoethylcarbamoyl)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-2'-AEC-cAMPS / Sp-2'-EDA-cAMPS )
   PDE-resistant Sp-cAMPS functionalized for immobilization or conjugation with markers and dyes .
A 095   5 umol / ~2.2 mg , 5 x 5 umol

N6- (6- Aminohexyl)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-6-AH-cAMPS )
   PDE-resistant Sp-cAMPS functionalized for immobilization or conjugation with markers and dyes.
A 089 CAS No.: [pending] 5 uM/~2.2 mg, 5 x 5 uM

N6- (6- Aminohexyl)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer, immobilized on agarose gel ( Sp-6-AH-cAMPS-Agarose )
   PDE-resistant Sp-cAMPS immobilized on Agarose. The gel can be used for affinity chromatography of various cyclic nucleotide-
   responsive proteins such as protein kinases, phosphodiesterases and others.
A 108   0.6 ml, 2.5 ml, 6 ml

2- (6- Aminohexylamino)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-2-AHA-cAMPS )
   PDE-resistant Sp-cAMPS functionalized for immobilization or conjugation with markers and dyes
A 068 CAS No.: [214276-94-5] 5 uM/~2.3 mg, 5 x 5 uM

8- (6- Aminohexylamino)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-8-AHA-cAMPS )
   PDE-resistant Sp-cAMPS functionalized for immobilization or conjugation with markers and dyes. PDE-stable cyclic AMP analogue
   suitable for immobilization as affinity ligand (e.g. for purification of phosphodiesterases) or for coupling of various labelling structures
   including fluorophores.
A 071 CAS No.: [214272-03-4] 5 uM/~2.3 mg, 5 x 5 uM

2- (6- Aminohexylamino)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer, immobilized to
   agarose gel ( Sp-2-AHA-cAMPS-Agarose )
   PDE-resistant Sp-cAMPS immobilized to agarose. The gel can be used for affinity chromatography of various cyclic nucleotide-
   responsive proteins such as protein kinases, phosphodiesterases and others.
A 069   0.6 ml, 2.5 ml, 6 ml

8- (6- Aminohexylamino)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer, immobilized on
   agarose gel ( Sp-8-AHA-cAMPS-Agarose )
   Immobilized PDE-resistant PKA agonist. The gel can be used for affinity chromatography of various cyclic nucleotide-responsive
   proteins such as protein kinases, phosphodiesterases and others.
A 013   0.6 ml, 2.5 ml, 6 ml

2'- O- (6- Aminohexylcarbamoyl)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-2'-AHC-cAMPS )
   PDE-resistant Sp-cAMPS functionalized for immobilization or conjugation with markers and dyes.
A 066 CAS No.: [pedding] 5 uM/~2.4 mg, 5 x 5 uM

N6- Benzoyladenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-6-Bnz-cAMPS )
   PDE-resistant and membrane-permeant activator of cAMP-dependent protein kinase. Sp-6-Bnz-cAMPS does not activate Epac and
   thus can be used as an Epac-negative control.
B 040   5 uM/~2.4 mg, 5 x 5 uM

8- Bromoadenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-8-Br-cAMPS )
   Metabolically resistant activator of protein kinase A (cyclic AMP agonist). No metabolic side effects as observed with dibutyryl-cAMP
   or 8-Br-cAMP. Significantly more lipophilic and membrane-permeant compared to Sp-cAMPS (Cat. No. A 003).
B 002 CAS No.: [127634-20-2] 5 uM/~2.2 mg, 5 x 5 uM

8- Bromoadenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer, acetoxymethyl ester ( Sp-8-Br-cAMPS-AM )
   Membrane-permeant precursor of the PDE-resistant protein kinase A activator Sp-8-Br-cAMPS (Cat. No. B 002). Metabolic
   bioactivation by esterases releases the active analogue, which is trapped inside the cell.
B 029 CAS No.: [pending] 1 uM/~0.5 mg, 5 x 1 uM

2- Chloroadenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-2-Cl-cAMPS )
   Analogue of the protein kinase A activator Sp-cAMPS (Cat. No. A003) with increased lipophilicity and phosphodiesterase stability.
B 074 CAS No.: [124854-63-3] 5 uM 5 x 5 uM

8- Chloroadenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-8-Cl-cAMPS )
   Metabolically resistant activator of protein kinase A (cyclic AMP agonist). No metabolic side effects as observed with 8-Cl-cAMP
   (Cat. No. C 007) and significantly more lipophilic and membrane-permeant.
C 004 CAS No.: [142754-28-7] 5 uM/~2 mg, 5 x 5 uM

8- (4- Chlorophenylthio)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-8-CPT-cAMPS )
   Lipophilic site-selective activator of protein kinase A (cyclic AMP agonist). Resistant against mammalian cyclic nucleotide-dependent
   phosphodiesterases, no metabolic side effects.
C 012 CAS No.: [129693-13-6] 5 uM/~2.5 mg, 5 x 5 uM

6- Chloropurine riboside- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-6-Cl-cPuMPS )
   PDE-resistant activator of protein kinase A (cyclic AMP agonist).
C 083 CAS No.: [129693-12-5] 5 uM 5 x 5 uM

5, 6- Dichlorobenzimidazole riboside- 3', 5' - cyclic monophosphorothioate, Sp- isomer ( Sp-5,6-DCl-cBIMPS )
   Potent site-selective activator of cAMP- dependent protein kinases especially suitable for intact cells showing preference for site B
   of type II isozyme. Completely stable against mammalian PDE types I & III and only extremely slowly hydrolized by cPDE type II.
   Surpasses the widely used but problematic dibutyryl cAMP or 8-CPT-cAMP in terms of metabolic stability, membrane permeability
   and potency.
D 014 CAS No.: [120912-54-1] 5 uM/~2.1 mg, 5 x 5 uM

8- Hydroxyadenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-8-OH-cAMPS )
   Polar, membrane-impermeant analogue of the protein kinase A activator Sp-cAMPS (Cat. No. A 003), e.g.
H 005 CAS No.: [749843-87-6] 5 uM/~1.9 mg, 5 x 5 uM

2'- O- Monobutyryladenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-2'-O-MB-cAMPS )
   Sp-2'-O-MB-cAMPS is a lipophilic precursor of Sp-cAMPS (Cat. No. A 003) a PDE-resistant activator of protein kinase A.
   During metabolic activation by esterases Sp-cAMPS and butyrate are released.
M 005 CAS No.: [152218-23-0] 5 uM/~2.2 mg, 5 x 5 uM

N6- Phenyladenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-6-Phe-cAMPS )
   PDE-resistant form of 6-Phe-cAMP (Cat. No. P 006), a potent site-selective, membrane-permeant activator of protein kinase A.
   Sp-6-Phe-cAMPS does not activate Epac and thus can be used as an Epac-negative control.
P 018 CAS No.: [169335-92-6] 5 uM/~2.2 mg, 5 x 5 uM

8- Piperidinoadenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-8-PIP-cAMPS )
   Lipophilic site-selective cyclic AMP analogue with extremely high selectivity for site B of protein kinase A type II. Acts synergistically
   with site A activating analogues for selective activation of type II. Metabolically stable and good membrane permeability.
P 005 CAS No.: [156816-35-2] 5 uM/~2.3 mg, 5 x 5 uM