Miscellaneous

  • Adenosine- 2', 3'- cyclic monophosphorothioate, Rp- / endo isomer ( Rp-2',3'-cAMPS )Cat. No.: A 006
  • Adenosine- 2', 3'- cyclic monophosphorothioate, Sp- / exo isomer ( Sp-2',3'-cAMPS )Cat. No.: A 024
  • Adenosine- 5'- O- phosphosulfate ( APS )Cat. No.: A 061
  • P1- (5'- Adenosyl)- P4- (5'- uridyl)- tetraphosphate / Uridine- adenosine- 5'- tetraphosphate ( Up4A )Cat. No.: U 008
  • Adenylyl- (3' --> 5')- adenosine ( ApA )Cat. No.: A 083
  • 8- Bromo- cyclic adenosine diphosphate ribose ( 8-Br-cADPR )Cat. No.: B 065
  • 8- Bromo- cyclic inosine diphosphate ribose ( 8-Br-N1-cIDPR )Cat. No.: B 071
  • Cyclic adenosine diphosphate ribose ( cADPR )Cat. No.: C 005
  • Cyclic diadenosine monophosphate ( c-diAMP ) / cyclic bis (3' → 5') diadenylic acidCat. No.: C 088
  • Cyclic diguanosine monophosphate ( c-diGMP ) / cyclic bis ( 3' → 5' ) diguanylic acidCat. No.: C 057
  • 2'- Deoxyadenosine- 3', 5'- O- bisphosphate ( pdAp )Cat. No.: D 092
  • 2'- Deoxycytidine- 3', 5'- O- bisphosphate ( pdCp )Cat. No.: D 093
  • 2'- Deoxyguanosine- 3', 5'- O- bisphosphate ( pdGp )Cat. No.: D 094
  • 2'-, 2''- O- ( Di- N'- methylanthraniloyl)- cyclic diguanosine monophosphate ( Di-MANT-c-diGMP )Cat. No.: D 101
  • 1, N6- Ethenoadenosine- 5'- O- diphosphoribose ( ε-ADPR / ε-ADP-ribose )Cat. No.: E 013
  • Ko-Libri Library of Nucleosides and NucleobasesCat. No.: K 001
  • β- Nicotinamide- 1, N6- ethenoadenine dinucleotide ( ε-NAD+ )Cat. No.: N 010
  • β- Nicotinamide- 8- bromohypoxanthine dinucleotide ( 8-Br-NHD+ )Cat. No.: N 006
  • 5'- Phosphoguanylyl- (3' → 5')- guanosine ( pGpG )Cat. No.: P 023
  • PKG inhibitor peptide DT-2Cat. No.: D 051
  • PKG inhibitor peptide DT-3Cat. No.: D 052
  • Thymidine- 3', 5'- O- bisphosphate ( pTp ) / 2'- Deoxythymidine- 3', 5'- O- bisphosphateCat. No.: T 012

     

  • Adenosine- 2', 3'- cyclic monophosphorothioate, Rp- / endo isomer ( Rp-2',3'-cAMPS )
       C10H11N5O5PS?Na; MW 367.3; λmax 258 nm; ε 15000; sodium salt, purity > 97% HPLC.
       Heaton & Eckstein, Nucleic Acids Res., 24, 850 - 853 (1996); Lowe & Thelin, J. Chem. Soc. Chem. Commun., 1947 - 1948 (1994).
    A 006 5 uM/ ~1.9 mg, 5 x 5 uM CAS No.: [118275-99-3]

    Adenosine- 2', 3'- cyclic monophosphorothioate, Sp- / exo isomer ( Sp-2',3'-cAMPS )
       C10H11N5O5PS?Na; MW 367.3; λmax 258 nm; ε 15000; sodium salt, purity > 97% HPLC.
       Heaton & Eckstein, Nucleic Acids Res., 24, 850 - 853 (1996).
    A 024 5 uM/ ~1.9 mg, 5 x 5 uM CAS No.: [118276-00-9]

    Adenosine- 5'- O- phosphosulfate ( APS )
       APS is a sulfate ester of adenosine- 5'- O- monophosphate (5'-AMP) and represents an active form of sulfate.
       Hofgen et al., Amino Acids, 20, 291 - 299 (2001); Eriksson et al., Anal. Biochem., 293, 67 - 70 (2001); Ronaghi et al., Science, 281, 363 - 365 (1998).
    A 061 10uM/ ~4.3 mg, 5 x 10 uM CAS No.: [102029-95-8]

    P1- (5'- Adenosyl)- P4- (5'- uridyl)- tetraphosphate / Uridine- adenosine- 5'- tetraphosphate ( Up4A )
       Synonym: P1- (5'- Adenosyl)- P4- (5’- uridyl)- tetraphosphate. Up4A is a dinucleoside polyphosphate containing both, a purine as well as a pyrimidine
       nucleobase moiety. It is considered to be a novel endothelium-derived vasoconstrictive factor. APS is a sulfate ester of adenosine- 5'- O- monophosphate
       (5'-AMP) and represents an active form of sulfate.
       Jankowski et al., Nature Medicine, 11, 223 - 227 (2005).
    U 008 1 uM/ ~0.8 mg, 5 x 1 uM CAS No.: [10527-48-7]

    Adenylyl- (3' --> 5')- adenosine ( ApA )
       C10H25N10O10P; MW 596.5 (free acid); sodium salt; purity > 95% HPLC.
    A 083   CAS No.: [2391-46-0]

    8- Bromo- cyclic adenosine diphosphate ribose ( 8-Br-cADPR )
       Antagonist of the second messenger cyclic ADP ribose.
       Walseth & Lee, Biochim. Biophys. Acta, 1178, 235 - 242 (1993); Guse, FEBS J., 272, 4590 - 4597 (2005); Guse et al., J. Biol. Chem., 280, 15952 - 15959 (2005). Jankowski et al., Nature Medicine, 11, 223 - 227 (2005).
    B 065 0.5 uM/ ~310 ug, 5 x 0.5 uM CAS No.: [151898-26-9]

    8- Bromo- cyclic inosine diphosphate ribose ( 8-Br-N1cIDPR )
       Membrane permeant and more stable analogue of the second messenger cyclic ADP ribose.
       Krichberger et al., Brit. J. Pharmacol., 149, 337 - 344 (2006)
    B 071 0.5 uM/ ~311 ug, 5 x 0.5 uM CAS No.: [638195-70-7]

    Cyclic adenosine diphosphate ribose ( cADPR )
       Modulates calcium release in many biological systems including plants. Second messenger, e.g. for glucose-induced insulin release.
       Lee et al., J. Biol. Chem., 264, 1608 - 1615 (1989); Dammermann & Guse, J. Biol. Chem., 280, 21394 - 21399 (2005); Gasser et al., J. Biol. Chem., 281, 2489 - 2496 (2006).
    C 005 0.5 uM/ ~270 ug, 5 x 0.5 uM CAS No.: [119340-53-3]

    Cyclic diadenosine monophosphate ( c-diAMP ) / cyclic bis (3' → 5') diadenylic acid
       c-diAMP may be an additional purine-based signalling nucleotide in prokaryotes .
       Witte et al., Mol. Cell, 30, 167 - 178 (2008), Simm et al., J. Bacteriol., 189, 3613 - 3623 (2007).
    C 088 0.1 uM/ ~66 ug, 5 x 0.1 uM CAS No.: [54447-84-6]

    Cyclic diguanosine monophosphate ( c-diGMP ) / cyclic bis ( 3' → 5' ) diguanylic acid
       Bacterial second messenger.
       Ross et al., Nature., 325, 279 - 281 (1987); Jenal, Curr. Opin. Microbiol., 7, 185 - 191 (2004); Simm et al., Mol. Microbiol., 53, 1123 - 1134 (2004); Karaolis et al., Biochem. Biophys.
       Res. Comm., 329, 40 - 45 (2005); Mendez-Ortiz et al., J. Biol. Chem., 281, 8090 - 8099 (2006).
    C 057 0.1 uM/ ~69 ug, 5 x 0.1 uM CAS No.: [61093-23-0]

    2'- Deoxyadenosine- 3', 5'- O- bisphosphate ( pdAp )
       Modulator of purinergic receptors.
       Camaioni et al., J. Med. Chem., 41, 183 - 190 (1998).
    D 092 5 uM/ ~2.1 mg, 5 x 5 uM CAS No.: [16174-58-6]

    2'- Deoxycytidine- 3', 5'- O- bisphosphate ( pdCp )
       Accepted by T4 RNA ligase to build oligodeoxyribonucleotides.
       Hinton et al., Biochemistry 17, 5091 - 5097 (1978).
    D 093 5 uM/ ~1.9 mg, 5 x 5 uM CAS No.: [4682-43-3]

    2'- Deoxyguanosine- 3', 5'- O- bisphosphate ( pdGp )
       C10H15N5O10P2; MW 427.2 (free acid); λmax 252 nm; ε 13500; sodium salt; purity > 95% HPLC.
    D 094 5 uM/ ~2.1 mg, 5 x 5 uM CAS No.: [16174-59-7]

    2'-, 2''- O- ( Di- N'- methylanthraniloyl)- cyclic diguanosine monophosphate ( Di-MANT-c-diGMP )
       Fluorescent analogue of the bacterial second messenger c-diGMP. The MANT fluorophore (λexc 355 nm, λem 448 nm) has a certain sensitivity for its
       environment and can change its spectral properties upon binding.
       Hiratsuka, Biochim. Biophys. Acta, 742, 496 - 503 (1983).
    D 101 0.1 uM/ ~0.1 mg, 5 x 0.1 uM CAS No.: [pending]

    1, N6- Ethenoadenosine- 5'- O- diphosphoribose ( ε-ADPR / ε-ADP-ribose )
       Fluorescent analogue of ADP-ribose (λexc 300 nm, λem 410 nm) that can be used in fluorometric assays.
       Bobalova et al., Anal. Biochem., 305, 269 - 276 (2002); Song et al., J. Biochem. Biophys. Methods, 63, 161 - 169 (2005).
    E 013 10 uM/ ~5.8 mg, 5 x 10 uM CAS No.: [69699-76-9]

    Ko-Libri Library of Nucleosides and Nucleobases1
       Compound library for screening
       Bobalova et al., Anal. Biochem., 305, 269 - 276 (2002); Song et al., J. Biochem. Biophys. Methods, 63, 161 - 169 (2005).
    K 001 10 mM/ 48 x 250ul  

    β- Nicotinamide- 1, N6- ethenoadenine dinucleotide ( ε-NAD+ )
       Fluorescent analogue of ß-NAD,. Fluorescent analogue of ß-NAD (λexc 309 nm, λem 415 nm) that can be used for a proof of ADP-ribosylation, for fluorometric
       assays and for preparation of fluorescent poly-ADP-ribose.
       Favilla & Mazzini, Biochim. Biophys. Acta, 788, 48 - 57 (1984); Klebl & Pette, Anal. Biochem., 239, 145 - 152 (1996);
       Shirato et al., Biochem. Biophys. Res. Commun., 355, 451 - 456 (2007).
    N 010 10 uM/ ~6.9 mg, 5 ea x 10 uM CAS No.: [38806-38-1]

    β- Nicotinamide- 8- bromohypoxanthine dinucleotide ( 8-Br-NHD+ )
        
       Wagner, G.K.; et al, Nucleic Acids Res. Suppl., 3, 1 - 2 (2003): "Analogues of Cyclic Adenosine 5'-Diphosphate Ribose and Adenophostin A, Nucleotides in Cellular Signal
       Transduction"    Wagner, G.K.; et al., Chem. Commun., 1944 - 1945 (2003): "First Enzymatic Synthesis of an N1-cyclised cADPR (cyclic - ADP Ribose) Analogue with a
       Hypoxanthine Partial Structure: Discovery of a Membrane Permeant cADPR Agonist"
    N 006   CAS No.: [477782-33-5]

    5'- Phosphoguanylyl- (3' → 5')- guanosine ( pGpG )
       First metabolic degradation product of the bacterial second messenger c-diGMP (Cat. No. C 057).
       Christen et al., Proc. Nat. Acad. Sci. USA, 104, 4112 - 4117 (2007).
    P 023 0.1 uM/ ~71 ug, 5 ea x 0.1 uM CAS No.: [33008-99-0]

    PKG inhibitor peptide DT-2
       Peptide-based inhibitor of protein kinase G type I alpha.
       Dostmann et al.: Proc. Natl. Acad. Sci. USA, 97, 14772 - 14777 (2000).
    D 051 0.5 uM/ ~0.18 mg, 5 ea x 0.5 uM CAS No.: [pending]

    PKG inhibitor peptide DT-3
       Peptide-based inhibitor of protein kinase G type I alpha.
       Dostmann et al.: Proc. Natl. Acad. Sci. USA, 97, 14772 - 14777 (2000).
    D 052 0.5 uM/ ~0.15 mg, 5 ea x 0.5 uM CAS No.: [pending]

    Thymidine- 3', 5'- O- bisphosphate ( pTp ) / 2'- Deoxythymidine- 3', 5'- O- bisphosphate
       Accepted by T4 RNA ligase to build oligodeoxyribonucleotides and competitive inhibitor of staphylococcal nuclease.
       Hinton et al., Biochemistry , 17, 5091 - 5097 (1978); Cuatrecasas et al., J. Biol. Chem., 242, 3063 - 3067 (1967).
    T 012 5 uM/ ~2 mg, 5 ea x 5 uM CAS No.: [2863-04-9]