cNMP with Pyrimidine Nucleobase

  • Adenosine- 3', 5'- cyclic monophosphate, acetoxymethyl ester ( cAMP-AM )Cat. No.: A 022
  • Adenosine- 3', 5'- monophosphorothioate acetoxymethyl ester, Sp- isomer ( Sp-cAMPS-AM )Cat. No.: A 035
  • 8- Bromo- 2'- O- methyladenosine- 3', 5'- cyclic monophosphate, acetoxymethyl ester ( 8-Br-2'-O-Me-cAMP-AM )Cat. No.: B 028
  • 8- Bromo- 2'- O- monobutyryladenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer ( Rp-8-Br-MB-cAMPS )Cat. No.: B 010
  • 8- Bromoadenosine- 3', 5'- cyclic monophosphate, acetoxymethyl ester ( 8-Br-cAMP-AM )Cat. No.: B 020
  • 8- Bromoadenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer, acetoxymethyl ester ( Sp-8-Br-cAMPS-AM )Cat. No.: B 029
  • 8- Chloroadenosine- 3', 5'- cyclic monophosphate, acetoxymethyl ester ( 8-Cl-cAMP-AM )Cat. No.: C 050
  • 8- (4- Chlorophenylthio)- 2'- O- methyladenosine- 3', 5'- cyclic monophosphate, acetoxymethyl ester ( 8-pCPT-2'-O-Me-cAMP-AM )Cat. No.: C 051
  • 8- (4- Chlorophenylthio)adenosine- 3', 5'- cyclic monophosphate, acetoxymethyl ester ( 8-CPT-cAMP-AM )Cat. No.: C 056
  • 8- (4- Chlorophenylthio)guanosine- 3', 5'- cyclic monophosphate, acetoxymethyl ester ( 8-pCPT-cGMP-AM )Cat. No.: C 033
  • Cytidine- 3', 5'- cyclic monophosphate, acetoxymethyl ester ( cCMP-AM )Cat. No.: C 067
  • N6, 2'- O- Dibutyryladenosine- 3', 5'- cyclic monophosphate ( DB-cAMP, Bucladesine ), economy gradeCat. No.: D 009 E
  • N6, 2'- O- Dibutyryladenosine- 3', 5'- cyclic monophosphate ( DB-cAMP, Bucladesine ), high purity gradeCat. No.: D 009
  • N6, 2'- O- Dibutyryladenosine- 3', 5'- cyclic monophosphate, acetoxymethyl ester ( DB-cAMP-AM )Cat. No.: D 008
  • N4, 2'- O- Dibutyrylcytidine- 3', 5'- cyclic monophosphate ( DB-cCMP )Cat. No.: D 075
  • N2, 2'- O- Dibutyrylguanosine- 3', 5'- cyclic monophosphate ( DB-cGMP )Cat. No.: D 010
  • Guanosine- 3', 5'- cyclic monophosphate, acetoxymethyl ester ( cGMP-AM )Cat. No.: G 002
  • 2'- O- (N- Methylanthraniloyl)adenosine- 3', 5'- cyclic monophosphate ( MANT-cAMP )Cat. No.: M 008
  • 2'- O- (N'- Methylanthraniloyl)cytidine- 3', 5'- cyclic monophosphate ( MANT-cCMP )Cat. No.: M 053
  • 2'- O- (N- Methylanthraniloyl)guanosine- 3', 5'- cyclic monophosphate ( MANT-cGMP )Cat. No.: M 009
  • 2'- O- Monobutyryladenosine- 3', 5'- cyclic monophosphate ( 2-MB-cAMP )Cat. No.: M 007
  • 2'- O- Monobutyryladenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer ( Rp-2'-O-MB-cAMPS )Cat. No.: M 004
  • 2'- O- Monobutyryladenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-2'-O-MB-cAMPS )Cat. No.: M 005
  • 2'- O- Monobutyrylguanosine- 3', 5'- cyclic monophosphate ( MB-cGMP )Cat. No.: M 006
     

  • Adenosine- 3', 5'- cyclic monophosphate, acetoxymethyl ester ( cAMP-AM )
       Membrane-permeant precursor of the second messenger cyclic AMP.
       Schultz et al., J. Biol. Chem., 268, 6316 - 6322 (1993).
    A 022 1 uM/~0.4 mg, 5 x 1 uM CAS No.: [159764-93-9]

    Adenosine- 3', 5'- monophosphorothioate acetoxymethyl ester, Sp- isomer ( Sp-cAMPS-AM )
       Membrane-permeant precursor of the PDE-resistant protein kinase A activator Sp-cAMPS.
       Schultz et al., J. Biol. Chem., 268, 6316 - 6322 (1993).
    A 035 1 uM/~0.4 mg, 5 x 1 uM CAS No.: [152218-24-1]

    8- Bromo- 2'- O- methyladenosine- 3', 5'- cyclic monophosphate, acetoxymethyl ester ( 8-Br-2'-O-Me-cAMP-AM )
       Extremely membrane-permeant precursor of the specific Epac agonist 8-Br-2'-O-Me-cAMP.
       Protected by patent n° EP 02077219.0 and foreign equivalents, exclusively licensed to BIOLOG LSI for research purposes only
    B 028   CAS No.: [pending]

    8- Bromo- 2'- O- monobutyryladenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer ( Rp-8-Br-MB-cAMPS )
       Lipophilic precursor of the protein kinase A inhibitor Rp-8-Br-cAMPS (Cat. No. B 001). During metabolic activation by esterases the inhibitor and butyrate are released.
       Ruiz-Velasco et al., Circ. Res., 82, 557 - 565 (1998).
    B 010 5 uM/ ~2.6 mg, 5 x 5 uM CAS No.: [788807-32-9]

    8- Bromoadenosine- 3', 5'- cyclic monophosphate, acetoxymethyl ester ( 8-Br-cAMP-AM )
       A membrane-permeant precursor of the PKA activator 8-Br-cAMP (Cat. No. B 007).
       Kruppa et al., Bioorg. Med. Chem. Lett., 7, 945 - 948 (1997); Moll et al., J. Neural. Transm., 113, 1015 - 1032 (2006).
    B 020 1 uM/ ~0.5 mg, 5 x 1 uM CAS No.: [190522-24-8]

    8- Bromoadenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer, acetoxymethyl ester ( Sp-8-Br-cAMPS-AM )
       Membrane-permeant precursor of the PDE-resistant protein kinase A activator Sp-8-Br-cAMPS (Cat. No. B 002).
       Maronde et al., J. Pineal Res., 31, 183 - 185 (2001).
    B 029 1 uM/ ~0.5 mg, 5 x 1 uM CAS No.: [pending]

    8- Chloroadenosine- 3', 5'- cyclic monophosphate, acetoxymethyl ester ( 8-Cl-cAMP-AM )
       Membrane-permeant precursor of the PKA activator 8-Cl-cAMP (Cat. No. C 007). Metabolic activation by esterases releases the polar active analogue, which is trapped inside the cell.
       J. Kruppa, Ph.D. thesis, University of Bremen, Germany, 1996.
    C 050 1 uM/ ~0.4 mg, 5 x 1 uM CAS No.: [pending]

    8- (4- Chlorophenylthio)- 2'- O- methyladenosine- 3', 5'- cyclic monophosphate, acetoxymethyl ester ( 8-pCPT-2'-O-Me-cAMP-AM )
       Extremely membrane-permeant precursor of the specific Epac agonist 8-CPT-2'-O-Me-cAMP. After permeation and metabolic activation by esterases the active compound is released.
       Vliem et al., ChemBioChem [Epub ahead of print] (2008).
    C 051   CAS No.: [pending]

    8- (4- Chlorophenylthio)adenosine- 3', 5'- cyclic monophosphate, acetoxymethyl ester ( 8-CPT-cAMP-AM )
       Membrane-permeant precursor of the PKA activator 8-CPT-cAMP (Cat. No. C 010). Metabolic activation by esterases releases the active analogue.
       Kruppa et al., Bioorg. Med. Chem. Lett., 7, 945 - 948 (1997).
    C 056 1 uM/ ~0.5 mg, 5 x 1 uM CAS No.: [663941-66-0]

    8- (4- Chlorophenylthio)guanosine- 3', 5'- cyclic monophosphate, acetoxymethyl ester ( 8-pCPT-cGMP-AM )
       Highly membrane-permeant precursor of the PKG activator 8-pCPT-cGMP (Cat. No. C 009). Metabolic activation by esterases releases the active analogue.
      Schwede et al., Bioorg. Med. Chem. Lett., 10, 571 - 573 (2000).
    C 033 1 uM/ ~0.6 mg, 5 x 1 uM CAS No.: [272445-72-4]

    Cytidine- 3', 5'- cyclic monophosphate, acetoxymethyl ester ( cCMP-AM )
       Membrane-permeant, metabolically activatable prodrug form of the potential further second messenger cyclic CMP. After permeation and metabolic activation by esterases the polar cCMP is released which is trapped inside the cell and subsequently metabolized quickly, resulting in a pulse-type signal.
      
    C 067 1 uM/ ~0.4 mg, 5 x 1 uM CAS No.: [pending]

    N6, 2'- O- Dibutyryladenosine- 3', 5'- cyclic monophosphate ( DB-cAMP, Bucladesine ), economy grade
       Membrane-permeant activator of protein kinase A (cyclic AMP agonist).
       Posternak et al., Methods Enzymol., 38, 399 (1974). C
    D 009 E 50 mg/ ~102uM, 5 x 50 mg CAS No.: [16980-89-5]

    N6, 2'- O- Dibutyryladenosine- 3', 5'- cyclic monophosphate ( DB-cAMP, Bucladesine ), high purity grade
       Membrane-permeant activator of protein kinase A (cyclic AMP agonist).
       Posternak et al., Methods Enzymol., 38, 399 (1974).
    D 009 100 uM/ ~49 mg, 5 x 100 uM CAS No.: [16980-89-5]

    N6, 2'- O- Dibutyryladenosine- 3', 5'- cyclic monophosphate, acetoxymethyl ester ( DB-cAMP-AM )
       Highly potent and membrane-permeant precursor of DB-cAMP. Releases dibutyryl cAMP after metabolic activation by esterases.
       Schultz et al., J. Biol. Chem., 268, 6316 - 6322 (1993).
    D 008 1 uM/ ~0.5 mg, 5 x 1 uM CAS No.: [159910-48-2]

    N4, 2'- O- Dibutyrylcytidine- 3', 5'- cyclic monophosphate ( DB-cCMP )
       Membrane-permeant, metabolically activatable prodrug form of the potential further second messenger cyclic CMP.
       Yanagida et al., Neurosci. Lett., 114, 323 - 328 (1990).
    D 075 10 uM/ ~4.7 mg, 5 x 10 uM CAS No.: [64649-87-2]

    N2, 2'- O- Dibutyrylguanosine- 3', 5'- cyclic monophosphate ( DB-cGMP )
       The metabolically released N2-monobutyryl cGMP is only a poor activator of cGMP- dependent protein kinase, and released butyrate can have its own side effects leading to misinterpretation of experimental results.
       Butt et al., Biochem. Pharmacol., 43, 2591 - 2600 (1992).
    D 010 50 uM/ ~25 mg, 5 x 50 uM CAS No.: [51116-00-8]

    Guanosine- 3', 5'- cyclic monophosphate, acetoxymethyl ester ( cGMP-AM )
       Membrane-permeant precursor of the second messenger cyclic GMP. Metabolic activation by esterases releases the polar active analogue which is trapped inside the cell.
       Schwede et al., Bioorg. Med. Chem. Lett., 10, 571 - 573 (2000).
    G 002 1 uM/ ~0.4 mg, 5 x 1 uM CAS No.: [164007-71-0]

    2'- O- (N- Methylanthraniloyl)adenosine- 3', 5'- cyclic monophosphate ( MANT-cAMP )
       Fluorescent cyclic AMP analogue, suitable for phosphodiesterase studies. The compound shows a decrease in fluorescence when cleaved by PDE.( λexc 350 nm, λem 445 nm)
       Hiratsuka, J. Biol. Chem., 257, 13354 - 13358 (1982); Kraemer et al., J. Mol. Biol., 306, 1167 - 1177 (2001).
    M 008 10 uM/ ~4.8 mg, 5 x 10 uM CAS No.: [83707-14-6]

    2'- O- (N'- Methylanthraniloyl)cytidine- 3', 5'- cyclic monophosphate ( MANT-cCMP )
       Fluorescent, membrane-permeant cyclic CMP analogue, potentially suitable for phosphodiesterase studies.( λexc 350 nm, λem 441 nm)
       Hiratsuka, J. Biol. Chem., 257, 13354 - 13358 (1982).
    M 053 5 uM/ ~2.3 mg, 5 x 5 uM CAS No.: [pending]

    2'- O- (N- Methylanthraniloyl)guanosine- 3', 5'- cyclic monophosphate ( MANT-cGMP )
       Fluorescent cyclic GMP analogue, suitable for phosphodiesterase studies.( λexc 350 nm, λem 441 nm)
       Hiratsuka, J. Biol. Chem., 257, 13354 - 13358 (1982); Johnson, Anal. Biochem., 162, 291 - 295 (1987); Brown et al., Biochem. Biophys. Res. Commun., 224, 684 - 689 (1996).
    M 009 10 uM/ ~5 mg, 5 x 10 uM CAS No.: [83707-15-7]

    2'- O- Monobutyryladenosine- 3', 5'- cyclic monophosphate ( 2-MB-cAMP )
       2'-O-MB-cAMP is a lipophilic precursor of cAMP. During metabolic activation by esterases cAMP and butyrate are released.
       Schaeffer et al., J. Pharmaceut. Sci., 72, 1255 - 1259 (1983).
    M 007 50 uM/ ~21 mg, 5 x 50 uM CAS No.: [55443-13-5]

    2'- O- Monobutyryladenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer ( Rp-2'-O-MB-cAMPS )
       Lipophilic precursor of Rp-cAMPS (Cat. No. A 002), a competitive inhibitor of protein kinase A. During metabolic activation by esterases the inhibitor and butyrate are released.
       Vischer et al., Blood, 91, 118 - 127 (1998).
    M 004 5 uM/ ~2.2 mg, 5 x 5 uM CAS No.: [152218-23-0]

    2'- O- Monobutyryladenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-2'-O-MB-cAMPS )
       Sp-2'-O-MB-cAMPS is a lipophilic precursor of Sp-cAMPS (Cat. No. A 003) a PDE-resistant activator of protein kinase A.
       Hugl et al., J. Biol. Chem., 273, 17771 - 17779 (1998).
    M 005 5 uM/ ~2.2 mg, 5 x 5 uM CAS No.: [152218-23-0]

    2'- O- Monobutyrylguanosine- 3', 5'- cyclic monophosphate ( MB-cGMP )
       2'-O-MB-cGMP is a lipophilic precursor of cyclic GMP. During metabolic activation by esterases cGMP and butyrate are released.
       Hebert et al., J. Biol. Chem., 273, 5557 - 5565 (1998).
    M 006 10 uM/ ~4.4 mg, 5 x 10 uM CAS No.: [58329-72-9]