Epac- negative Controls

N6- Benzoyladenosine- 3', 5'- cyclic monophosphate ( 6-Bnz-cAMP )
   Membrane-permeant, site-selective PKA agonist.
   Christensen et al., J. Biol. Chem., 278, 35394 - 35402 (2003); Bos, Trends Biochem. Sci., 31, 680 - 686 (2006).
B 009 10 uM/~4.6 mg, 5 x 10 uM CAS No.: [30275-80-0]

N6- Benzoyladenosine- 3', 5'- cyclic monophosphate, acetoxymethyl ester ( 6-Bnz-cAMP-AM )
   Metabolically activatable, highly membrane-permeant PKA agonist.
  
B 079 1 umol / ~0.5 mg10, 5 x 1 umol  

N6- Benzoyladenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-6-Bnz-cAMPS )
   PDE-resistant and membrane-permeant activator of cAMP-dependent protein kinase. Sp-6-Bnz-cAMPS does not activate Epac and thus can be
   used as an Epac-negative control.
   Protected under patent DE 3802865.4 exclusively licensed to BIOLOG LSI
B 040 5 uM/~2.4 mg, 5 x 5 uM CAS No.: [152218-18-3]

N6- Benzyladenosine- 3', 5'- cyclic monophosphate ( 6-Bn-cAMP )
   Site selective activator of cAMP-dependent protein kinase which does not activate Epac.
   Pepe et al., Cancer Res., 51, 6263 - 6267 (1991).
B 008 10 uM/~4.4 mg, 5 x 10 uM CAS No.: [32115-08-5]

8- Bromo- 2'- O- methylguanosine- 3', 5'- cyclic monophosphate ( 8-Br-2'-O-Me-cGMP )
   Analogue of cyclic GMP which does not activate both, protein kinase G and Epac. 8-Br-2'-O-Me-cGMP can be used as an inactive control versus 8-Br-cGMP.
   Protected by patent n° EP 02077219.0 and foreign equivalents, exclusively licensed to BIOLOG LSI for research purposes only
B 037 5 uM/~1.9 mg, 5 x 5 uM CAS No.: [pending]

8- (4- Chlorophenylthio)- 2'- O- methylguanosine- 3', 5'- cyclic monophosphate ( 8-pCPT-2'-O-Me-cGMP )
   The membrane-permeant 8-pCPT-2'-O-Me-cGMP neither activate protein kinase G nor Epac and can thus be used as a control.
   Protected by patent n° EP 02077219.0 and foreign equivalents, exclusively licensed to BIOLOG LSI for research purposes only
C 048 5 uM/~2.6 mg, 5 x 5 uM CAS No.: [625112-42-7]

8- (4- Chlorophenylthio)- 2'- O- methylxanthosine- 3', 5'- cyclic monophosphate ( 8-pCPT-2'-O-Me-cXMP )
   The membrane-permeant 8-pCPT-2'-O-Me-cXMP neither activate protein kinase G nor Epac and thus can be used as a control.
   Protected by patent n° EP 02077219.0 and foreign equivalents, exclusively licensed to BIOLOG LSI for research purposes only
C 059 5 uM/~2.6 mg, 5 x 5 uM CAS No.: [pending]

N6, 2'- O- Dibutyryladenosine- 3', 5'- cyclic monophosphate ( DB-cAMP, Bucladesine ), economy grade
   Membrane-permeant activator of protein kinase A (cyclic AMP agonist). This analogue releases butyrate due to intracellular and extracellular esterase action.
   Posternak et al., Methods Enzymol., 38, 399 (1974).
D 009 E 50 mg/ ~102uM, 5 x 50 mg CAS No.: [16980-89-5]

N6, 2'- O- Dibutyryladenosine- 3', 5'- cyclic monophosphate ( DB-cAMP, Bucladesine ), high purity grade
   Membrane-permeant activator of protein kinase A (cyclic AMP agonist). This analogue releases butyrate due to intracellular and extracellular esterase action.
   Posternak et al., Methods Enzymol., 38, 399 (1974).
D 009 100 uM/ ~49mg, 5 x 100 uM CAS No.: [16980-89-5]

2'- O- Methylguanosine- 3', 5'- cyclic monophosphate ( 2'-O-Me-cGMP )
   Relatively polar analogue of cyclic GMP which activate neither protein kinase G nor Epac. 2'-O-Me-cGMP can be used as an inactive control
   in patch clampapplications.
   Kang et. al., J. Physiol., 573, 595 - 609 (2006).
M 036 5 uM/ ~1.9mg, 5 x 5 uM CAS No.: [pending]

N6- Mono- tert. butylcarbamoyladenosine- 3', 5'- cyclic monophosphate ( 6-MBC-cAMP )
   Site selective activator of protein kinase A ( cyclic AMP agonist ) strongly preferring the A site of cAK II.
   Maronde et al., J. Pineal Res., 27, 170 - 182 (1999); Fricke et al., Endocrinology, 145, 4940 - 4947 (2004).
M 012 5 uM/ ~2.3mg, 5 x 5 uM CAS No.: [84433-46-5]

N6- Monobutyryladenosine- 3', 5'- cyclic monophosphate ( 6-MB-cAMP )
   Membrane-permeant, site-selective activator of protein kinase A (cyclic AMP agonist). 6-MB-cAMP does not activate Epac and thus can be used
   as an Epac-negative control.
   Kopperud et al., FEBS Lett., 546, 121 - 126 (2003).
M 003 50 uM/ ~21mg, 5 x 50 uM CAS No.: [70253-67-7]

N6- Phenyladenosine- 3', 5'- cyclic monophosphate ( 6-Phe-cAMP )
   Potent site-selective activator of protein kinase A showing strong preference for site A of both isozymes.
   Kloss et al., Mol. Pharmacol., 65, 1440 - 1451 (2004).
P 006 5 uM/ ~2.1mg, 5 x 5 uM CAS No.: [34051-30-4]

N6- Phenyladenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-6-Phe-cAMPS )
   PDE-resistant form of 6-Phe-cAMP (Cat. No. P 006), a potent site-selective, membrane-permeant activator of protein kinase A. Sp-6-Phe-cAMPS
   does not activate Epac and thus can be used as an Epac-negative control.
   Gjertsen et al., J. Biol. Chem., 270, 20599 - 20607 (1995).
P 018 5 uM/ ~2.2mg, 5 x 5 uM CAS No.: [169335-92-6]