Epac Agonists


8- (2- Aminoethylamino)adenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer ( Rp-8-AEA-cAMPS )
   Phosphodiesterase-resistant ligand for affinity chromatography of cAMP and cGMP binding proteins and suitable for modification with fluorophores and other markers
A 180   CAS No.: [221904-78-5]   5 uM, 5 x 5uM

8- (2- Aminoethylthio)- 2'- O- methyladenosine- 3', 5'- cyclic monophosphate ( 8-AET-2'-O-Me-cAMP )
   8-AET-2´-O-Me-cAMP has only poor affinity towards protein kinases A and G and is thus suitable as a ligand in affinity chromatography of cAMP binding proteins that do not require an intact 2´-OH group, such as the exchange protein activated by cyclic AMP (Epac) and certain phosphodiesterases.
A 142   CAS No.: [634207-89-9]   5 uM, 5 x 5uM
8- (6- Aminohexylamino)- 2'- O- methyladenosine- 3', 5'- cyclic monophosphate ( 8-AHA-2'-O-Me-cAMP )
   8-AHA-2'-O-Me-cAMP has only poor affinity towards protein kinases A and G and is thus suitable as a ligand in affinity chromatographyof cAMP
   binding proteins that do not require an intact 2'-OH group, such as the exchange protein activated by cyclic AMP (Epac) and certain phosphodiesterases.
A 099 CAS No.: [pending] 5 uM/~2.3mg, 5 x 5 uM

8- (6- Aminohexylamino)- 2'- O- methyladenosine- 3', 5'- cylic monophosphate, immobilized on agarose
   ( 8-AHA-2'-O-Me-cAMP-Agarose )
   Considered to be suitable for affinity chromatography of various cAMP-responsive proteins, especially those which tolerate modificationof the
   ribose 2'-hydroxy group, such as the exchange protein activated by cyclic AMP (Epac) and certain phosphodiesterases.
A 057 CAS No.: [pending] 0.6 ml, 2.5 ml, 6 ml

8- Bromo- 2'- O- methyladenosine- 3', 5'- cyclic monophosphate ( 8-Br-2'-O-Me-cAMP )
   Specific activator of the exchange protein activated by cyclic AMP (Epac) or cAMP-GEF, respectively, while protein kinase A is not affected. Suitable for
   direct comparison with common 8-Br-cAMP, which activates both, PKA and Epac.
B 022 CAS No.: [612513-13-0] 5 uM/~2.2mg, 5 x 5 uM

8- Bromo- 2'- O- methyladenosine- 3', 5'- cyclic monophosphate, acetoxymethyl ester ( 8-Br-2'-O-Me-cAMP-AM )
   Extremely membrane-permeant precursor of the specific Epac agonist 8-Br-2'-O-Me-cAMP. After permeation and metabolic activation by esterases
   the active compound is released.
B 028    

8- Bromo- 2'- O- methyladenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-8-Br-2'-O-Me-cAMPS )
   PDE-resistant, membrane-permeant Epac agonist
B 031   CAS No.: [634208-34-7]   1 umol / ~0.5 mg, 5 x 1 umol

8- (4- Chlorophenylthio)- 2'- O- methyladenosine- 3', 5'- cyclic monophosphate ( 8-pCPT-2'-O-Me-cAMP / "007" )
   Specific activator of the exchange protein activated by cyclic AMP (Epac) or cAMP-GEF, respectively, which does not activate protein kinase A.
   High lipophilicity and membrane permeability, as well as increased PDE stability.
C 041 CAS No.: [510774-50-2] 5 uM/~2.5 mg, 5 x 5 uM

8- (4- Chlorophenylthio)- 2'- O- methyladenosine- 3', 5'- cyclic monophosphate, acetoxymethyl ester ( 8-pCPT-2'-O-Me-cAMP-AM )
   Metabolically activatable, highly membrane-permeant Epac agonist.
C 051 CAS No.: [pending]  

8- (4- Chlorophenylthio)- 2'- O- methyladenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-8-pCPT-2'-O-Me-cAMPS )
   Hydrolysis-resistant form of 8-pCPT-2'-O-Me-cAMP (Cat. No. C 041), a specific activator of the exchange protein directly activated by cyclic AMP
   (Epac) or cAMP-GEF, respectively. The compound does not activate protein kinase A, has high lipophilicity and membrane permeability and
   is not metabolized by phosphodiesterases.
C 052 CAS No.: [634208-37-0] 1 uM/~0.5 mg, 5 x 1 uM

8- (4- Chlorophenylthio)adenosine- 3', 5'- cyclic monophosphate ( 8-CPT-cAMP ), economy grade
   Lipophilic activator of both cAMP- and cGMP-dependent protein kinase and of Epac
C 010 E CAS No.: [93882-12-3] 50mg/~102uM, 5 x 50mg

8- (4- Chlorophenylthio)adenosine- 3', 5'- cyclic monophosphate ( 8-CPT-cAMP ), fluorescence grade
   Lipophilic activator of both cAMP- and cGMP-dependent protein kinase and of Epac
C 010 CAS No.: [93882-12-3] 100uM/~49mg, 5 x 100uM

8- (2- [ DY-547]- aminoethylthio)- 2'- O- methyladenosine- 3', 5'- cyclic monophosphate ( 8-[DY-547]-AET-2'-O-Me-cAMP )
   Fluorescent activator of the exchange protein directly activated by cyclic AMP (Epac) or cAMP-GEF, respectively, does not activate PKA.
D 089 CAS No.: [pending] 0.1 uM/~0.1 mg, 5 x 0.1 uM

8- Hydroxy- 2'- O- methyladenosine- 3', 5'- cyclic monophosphate ( 8-OH-2'-O-Me-cAMP )
   Specific activator of the exchange protein activated by cyclic AMP (Epac) or cAMP-GEF, respectively, which does not activate protein kinase A.
   Due to its low lipophilicity and membrane permeability, 8-OH-2'-O-Me-cAMP can be used in patch clamp applications.
H 013 CAS No.: [pending] 5 uM/~1.9 mg, 5 x 5 uM

8- (4- Hydroxyphenylthio)- 2'- O- methyladenosine- 3', 5'- cyclic monophosphate ( 8-pHPT-2'-O-Me-cAMP )
   Specific activator of the exchange protein activated by cyclic AMP (Epac) or cAMP-GEF, respectively, which does not activate protein kinase A.
   High lipophilicity and membrane permeability, as well as increased PDE stability.
H 010 CAS No.: [612513-15-2] 5 uM/~2.4 mg, 5 x 5 uM

8- (4- Methoxyphenylthio)- 2'- O- methyladenosine- 3', 5'- cyclic monophosphate ( 8-pMeOPT-2'-O-Me-cAMP )
   Very potent and specific activator of the exchange protein activated by cyclic AMP (Epac) or cAMP-GEF, respectively, which does not activate
   protein kinase A. High lipophilicity and membrane permeability, as well as increased PDE stability.
M 034 CAS No.: [612513-16-3] 5 uM/~2.5 mg, 5 x 5 uM

2'- O- Methyladenosine- 3', 5'- cyclic monophosphate ( 2'-O-Me-cAMP )
   Relatively polar analogue of cyclic AMP which does not activate protein kinase A. Suitable for Epac activation by patch clamp application
   techniques and for receptor mapping studies.
M 050 CAS No.: [40269-29-2] 5 uM/~1.8 mg, 5 x 5 uM

8- [ Pharos-575]- 2'- O- methyladenosine- 3', 5'- cyclic monophosphate ( 8-[φ-575]-2'-O-Me-cAMP )
   Fluorescent Epac agonist. The fluorophore can be excited e.g. by a Kr/Ar laser. Due to its high lipophilicity and bright red fluorescence 8-[φ-575]-
   cAMP is especially suitable for studies with intact cells.
P 021 CAS No.: [pending] 0.1 uM/~74 ug, 5 x 0.1 uM