cAMP Ligands for Immobilization

  • 2'- O- (2- Aminoethylcarbamoyl)adenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer ( Rp-2'-AEC-cAMPS / Rp-2'-EDA-cAMPS )Cat. No.: A 119
  • 2'- Amino- 2'- deoxyadenosine- 3', 5'- cyclic monophosphate ( 2'-NH2-cAMP )Cat. No.: A 088
  • 8- (8- Amino- 3, 6- dioxaoctylamino)adenosine- 3', 5'- cyclic monophosphate ( 8-ADOA-cAMP )Cat. No.: A 033
  • 8- (4- Aminobutylamino)adenosine- 3', 5'- cyclic monophosphate ( 8-ABA-cAMP )Cat. No.: A 017
  • N6- (2- Aminoethyl)- 8- azidoadenosine- 3', 5'- cyclic monophosphate ( 6-AE-8-N3-cAMP )Cat. No.: A 101
  • N6- (2- Aminoethyl)adenosine- 3', 5'- cyclic monophosphate ( 6-AE-cAMP )Cat. No.: A 096
  • N6- (2- Aminoethyl)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-6-AE-cAMPS )Cat. No.: A 092
  • 2- (2- Aminoethylamino)adenosine- 3', 5'- cyclic monophosphate ( 2-AEA-cAMP )Cat. No.: A 097
  • 8- (2- Aminoethylamino)adenosine- 3', 5'- cyclic monophosphate ( 8-AEA-cAMP )Cat. No.: A 016
  • 2- (2- Aminoethylamino)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-2-AEA-cAMPS )Cat. No.: A 093
  • 8- (2- Aminoethylamino)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-8-AEA-cAMPS )Cat. No.: A 094
  • 2'- O- (2- Aminoethylcarbamoyl)adenosine- 3', 5'- cyclic monophosphate ( 2'-AEC-cAMP / 2'-EDA-cAMP )Cat. No.: A 098
  • 2'- O- (2- Aminoethylcarbamoyl)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-2'-AEC-cAMPS / Sp-2'-EDA-cAMPS )Cat. No.: A 095
  • N6- (6- Aminohexyl)adenosine- 3', 5'- cyclic monophosphate ( 6-AH-cAMP )Cat. No.: A 031
  • N6- (6- Aminohexyl)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-6-AH-cAMPS )Cat. No.: A 089
  • 8- (6- Aminohexylamino)- 2'- O- methyladenosine- 3', 5'- cyclic monophosphate ( 8-AHA-2'-O-Me-cAMP )Cat. No.: A 099
  • 2- (6- Aminohexylamino)adenosine- 3', 5'- cyclic monophosphate ( 2-AHA-cAMP )Cat. No.: A 053
  • 8- (6- Aminohexylamino)adenosine- 3', 5'- cyclic monophosphate ( 8-AHA-cAMP )Cat. No.: A 011
  • 8- (6- Aminohexylamino)adenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer ( Rp-8-AHA-cAMPS )Cat. No.: A 085
  • 2- (6- Aminohexylamino)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-2-AHA-cAMPS )Cat. No.: A 068
  • 8- (6- Aminohexylamino)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-8-AHA-cAMPS )Cat. No.: A 071
  • 2'- (6- Aminohexylcarbamoyl)adenosine- 3', 5'- cyclic monophosphate ( 2'-AHC-cAMP )Cat. No.: A 046
  • 2'- O- (6- Aminohexylcarbamoyl)adenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer ( Rp-2'-AHC-cAMPS )Cat. No.: A 120
  • 2'- (6- Aminohexylcarbamoyl)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-2'-AHC-cAMPS )Cat. No.: A 066
  • 8- Azido- 1, N6- ethenoadenosine- 3', 5'- cyclic monophosphate ( 8-N3-ε-cAMP ) Cat. No.: A 077
  • 8- Azido- N6- (2- [DY-547]- aminoethyl)adenosine- 3', 5'- cyclic monophosphate ( 8-N3-6-[DY-547]-AE-cAMP ) Cat. No.: A 100
  • 8- Azido- N6- (6- [biotinyl]aminoethyl)adenosine- 3', 5'- cyclic monophosphate ( 8-N3-6-[Biotin]-AE-cAMP ) Cat. No.: A 127
  • 8- Azidoadenosine- 3', 5'- cyclic monophosphate ( 8-N3-cAMP ) Cat. No.: A 014
  • 2'- O- Monosuccinyladenosine- 3', 5'- cyclic monophosphate ( 2'-O-MS-cAMP ) Cat. No.: M 011

     

  • 2'- O- (2- Aminoethylcarbamoyl)adenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer
       ( Rp-2'-AEC-cAMPS / Rp-2'-EDA-cAMPS )
       Analogue of Rp-cAMPS, suitable for immobilization as affinity ligand (e.g. for purification of phosphodiesterases or protein kinase A) or for coupling of various
       labelling structures including fluorophores.
    A 119 5 uM/ ~2.2 mg, 5 x 5 uM CAS No.: [pending]

    2'- Amino- 2'- deoxyadenosine- 3', 5'- cyclic monophosphate ( 2'-NH2-cAMP )
       2'-NH2-cAMP has a reactive amino group suitable for modification with fluorophores and other markers or spacers and can be used as ligand for affinity
       chromatography of cAMP and cGMP binding proteins that do not require an intact 2'-OH group.
    A 088 5 uM/ ~1.8 mg, 5 x 5 uM CAS No.: [85819-83-6]

    8- (8- Amino- 3, 6- dioxaoctylamino)adenosine- 3', 5'- cyclic monophosphate ( 8-ADOA-cAMP )
       Site selective cAMP analogue with a hydrophilic spacer, suitable as a ligand in affinity chromatography and for modification with fluorophores.
       Moll et al., J. Neural. Transm., 113, 1015 - 1032 (2006).
    A 033 5 uM/ ~2.4 mg, 5 x 5 uM CAS No.: [214272-05-6]

    8- (4- Aminobutylamino)adenosine- 3', 5'- cyclic monophosphate ( 8-ABA-cAMP )
       Site selective cAMP analogue with preference for site B of R I of cAMP-dependent protein kinase. Suitable as a ligand in affinity chromatography and for modification with fluorophores or other markers.
       Schwede et al., Biochemistry, 39, 8803 - 8812 (2000).
    A 017 5 uM/ ~2.1 mg, 5 x 5 uM CAS No.: [82927-68-2]

    N6- (2- Aminoethyl)- 8- azidoadenosine- 3', 5'- cyclic monophosphate ( 6-AE-8-N3-cAMP )
       6-AE-8-N3-cAMP is a light sensitive analogue for photoaffinity labelling. It can be immobilized within a cyclic AMP binding site by illumination with UV light.
       The reactive amino group connected to position 6 of the adenine nucleobase can be used to form a conjugate with suitable reporter groups, such as
       fluorescent dyes or biotin, etc.
    A 101 1 uM/ ~0.4 mg, 5 x 1 uM CAS No.: [pending]

    N6- (2- Aminoethyl)adenosine- 3', 5'- cyclic monophosphate ( 6-AE-cAMP )
       Ligand for affinity chromatography of cAMP and cGMP binding proteins and suitable for modification with fluorophores and other markers.
       Dills et al., Biochemistry, 15, 3724 - 3731 (1976).
    A 096 5 uM/ ~1.9 mg, 5 x 5 uM CAS No.: [66311-08-8]

    N6- (2- Aminoethyl)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-6-AE-cAMPS )
       Phosphodiesterase-resistant ligand for affinity chromatography of cAMP and cGMP binding proteins and suitable for modification with fluorophores and other markers.
    A 092 5 uM/ ~1.9 mg, 5 x 5 uM CAS No.: [pending]

    2- (2- Aminoethylamino)adenosine- 3', 5'- cyclic monophosphate ( 2-AEA-cAMP )
       Ligand for affinity chromatography of cAMP and cGMP binding proteins and suitable for modification with fluorophores and other markers.
       Rieke et al., Eur. J. Biochem., 83, 419 - 426 (1978).
    A 097 5 uM/ ~1.9 mg, 5 x 5 uM CAS No.: [66311-12-4]

    8- (2- Aminoethylamino)adenosine- 3', 5'- cyclic monophosphate ( 8-AEA-cAMP )
       Ligand for affinity chromatography of cAMP and cGMP binding proteins and suitable for modification with fluorophores and other markers.
       Ramseyer et al., Biochim. Biophys. Acta, 446, 358 - 370 (1976).
    A 016 5 uM/ ~1.9 mg, 5 x 5 uM CAS No.: [61363-29-9]

    2- (2- Aminoethylamino)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-2-AEA-cAMPS )
       Phosphodiesterase-resistant ligand for affinity chromatography of cAMP and cGMP binding proteins and suitable for modification with fluorophores and
       other markers.
    A 093 5 uM/ ~2.0 mg, 5 x 5 uM CAS No.: [pending]

    8- (2- Aminoethylamino)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-8-AEA-cAMPS )
       Phosphodiesterase-resistant ligand for affinity chromatography of cAMP and cGMP binding proteins and suitable for modification with fluorophores and
       other markers.
    A 094 5 uM/ ~2.0 mg, 5 x 5 uM CAS No.: [221904-84-3]

    2'- O- (2- Aminoethylcarbamoyl)adenosine- 3', 5'- cyclic monophosphate ( 2'-AEC-cAMP / 2'-EDA-cAMP )
       Ligand for affinity chromatography of cAMP and cGMP binding proteins and suitable for modification with fluorophores and other markers.
    A 098 5 uM/ ~2.1 mg, 5 x 5 uM CAS No.: [403497-54-1]

    2'- O- (2- Aminoethylcarbamoyl)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer
       ( Sp-2'-AEC-cAMPS / Sp-2'-EDA-cAMPS )
       Phosphodiesterase-resistant ligand for affinity chromatography of cAMP and cGMP binding proteins and suitable for modification with fluorophores and
       other markers.
    A 095 5 uM/ ~2.2 mg, 5 x 5 uM CAS No.: [pending]

    N6- (6- Aminohexyl)adenosine- 3', 5'- cyclic monophosphate ( 6-AH-cAMP )
       Suitable as a ligand in affinity chromatography of cAMP and cGMP binding proteins and for modification with fluorophores and other markers.
       Dills et al., Biochemistry, 15, 3724 - 3731 (1976); Moll et al., J. Neural. Transm., 113, 1015 - 1032 (2006).
    A 031 5 uM/ ~2.1 mg, 5 x 5 uM CAS No.: [66311-09-9]

    N6- (6- Aminohexyl)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-6-AH-cAMPS )
       Phosphodiesterase-resistant ligand for affinity chromatography of cAMP and cGMP binding proteins and suitable for modification with fluorophores and
       other markers.
    A 089 5 uM/ ~2.2 mg, 5 x 5 uM CAS No.: [pending]

    8- (6- Aminohexylamino)- 2'- O- methyladenosine- 3', 5'- cyclic monophosphate ( 8-AHA-2'-O-Me-cAMP )
       8-AHA-2'-O-Me-cAMP has only poor affinity towards protein kinases A and G and is thus suitable as a ligand in affinity chromatography of cAMP binding
       proteins that do not require an intact 2'-OH group, such as the exchange protein activated by cyclic AMP (Epac) and certain phosphodiesterases.
    A 099 5 uM/ ~2.3 mg, 5 x 5 uM CAS No.: [pending]

    2- (6- Aminohexylamino)adenosine- 3', 5'- cyclic monophosphate ( 2-AHA-cAMP )
       Suitable as a ligand in affinity chromatography (2-AHA-cAMP-Agarose; Cat. No. A 054) and for modification with fluorophores.
       Moll et al., J. Neural. Transm., 113, 1015 - 1032 (2006).
    A 053 5 uM/ ~2.2 mg, 5 x 5 uM CAS No.: [214276-80-9]

    8- (6- Aminohexylamino)adenosine- 3', 5'- cyclic monophosphate ( 8-AHA-cAMP )
       Site selective cAMP analogue with preference for site B of R I of cAMP-dependent protein kinase. In combination with 8-PIP-cAMP (Cat. No. P 002), which
       selects site A of R I and site B of R II specific synergistic activation of kinase type I can be obtained.
       Skalhegg et al., J. Biol. Chem., 267, 15707 - 15714 (1992). Herberg et al., J. Mol. Biol., 298, 329 - 339 (2000), Moll et al., J. Neural. Transm., 113, 1015 - 1032 (2006)
    A 011 10 uM/ ~4.4 mg, 5 x 10 uM CAS No.: [39824-30-1]

    8- (6- Aminohexylamino)adenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer ( Rp-8-AHA-cAMPS )
       Analogue of Rp-cAMPS, suitable for immobilization as affinity ligand (e.g. for purification of phosphodiesterases or proteinkinase A) or for coupling of various
       labeling structures including fluorophores.
       Liauw et al., Rev. Roum. Chim., 43, 241 - 253 (1998).
    A 085 5 uM/ ~2.3 mg, 5 x 5 uM CAS No.: [214272-02-3]

    2- (6- Aminohexylamino)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-2-AHA-cAMPS )
       Phosphodiesterase-resistant ligand for affinity chromatography of cAMP and cGMP binding proteins and suitable for modification with fluorophores and
       other markers.
    A 068 5 uM/ ~2.3 mg, 5 x 5 uM CAS No.: [214276-94-5]

    8- (6- Aminohexylamino)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-8-AHA-cAMPS )
       PDE-stable cyclic AMP analogue suitable for immobilization as affinity ligand (e.g. for purification of phosphodiesterases) or for coupling of various labelling
       structures including fluorophores.
       Moll et al., J. Neural. Transm., 113, 1015 - 1032 (2006).
    A 071 5 uM/ ~2.3 mg, 5 x 5 uM CAS No.: [214272-03-4]

    2'- (6- Aminohexylcarbamoyl)adenosine- 3', 5'- cyclic monophosphate ( 2'-AHC-cAMP )
       Cyclic AMP analogue suitable for immobilization as affinity ligand (e.g. for purification of phosphodiesterases) or for coupling of various labelling structures including fluorophores.
       Corrie et al., Prot. Expr. Purif., 3, 417 - 420 (1992).
    A 046 5 uM/ ~2.4 mg, 5 x 5 uM CAS No.: [pending]

    2'- O- (6- Aminohexylcarbamoyl)adenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer ( Rp-2'-AHC-cAMPS )
       Analogue of Rp-cAMPS, suitable for immobilization as affinity ligand (e.g. for purification of phosphodiesterases or protein kinase A) or for coupling of various
       labelling structures including fluorophores.
    A 120 5 uM/ ~2.4 mg, 5 x 5 uM CAS No.: [pending]

    2'- (6- Aminohexylcarbamoyl)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer ( Sp-2'-AHC-cAMPS )
       PDE-stable cyclic AMP analogue suitable for immobilization as affinity ligand (e.g. for purification of phosphodiesterases) or for coupling of various labelling
       structures including fluorophores.
       Corrie et al., Prot. Expr. Purif., 3, 417 - 420 (1992).
    A 066 5 uM/ ~2.4 mg, 5 x 5 uM CAS No.: [pending]

    8- Azido- 1, N6- ethenoadenosine- 3', 5'- cyclic monophosphate ( 8-N3-ε-cAMP )
       Nonfluorescent cAMP analogue, that can be used for labelling of cAMP receptors. Upon UV-light-induced immobilization the ethenoadenine moiety starts to
       fluoresce, providing a label for tracing the receptor protein.
       Keeler & Campbell, Biochem. Biophys. Res. Commun., 72, 575 - 80 (1976); Dreyfuss et al., Proc. Nat. Acad. Sci. USA, 75, 1199 - 1203 (1978).
    A 077 1 uM/ ~0.4 mg, 5 x 1 uM CAS No.: [60902-12-7]

    8- Azido- N6- (2- [DY-547]- aminoethyl)adenosine- 3', 5'- cyclic monophosphate ( 8-N3-6-[DY-547]-AE-cAMP )
       8-N3-6-[DY547]-AE-cAMP is a light sensitive analogue for photoaffinity labelling. It can be immobilized within a cyclic AMP binding site by illumination with UV
       light. The fluorescent reporter group connected to position 6 of the adenine nucleobase can be excitated at 557 nm and emits with 574 nm.
    A 100 0.1 uM/ ~0.1 mg, 5 x 0.1 uM CAS No.: [pending]

    8- Azido- N6- (6- [biotinyl]aminoethyl)adenosine- 3', 5'- cyclic monophosphate ( 8-N3-6-[Biotin]-AE-cAMP )
       Analogue for photoaffinity labelling of cAMP binding proteins which can be immobilized by UV light. The biotin label is connected to the 6-position of cyclic
       AMP via a 15 atom spacer.
    A 127 0.1 uM/ ~80 ug, 5 x 0.1 uM CAS No.: [pending]

    8- Azidoadenosine- 3', 5'- cyclic monophosphate ( 8-N3-cAMP )
       Analogue for photoaffinity labelling of cAMP binding proteins.
       Haley, Methods Enzymol., 46, 339 - 346 (1977).
    A 014 10 uM/ ~3.9 mg, 5 x 10 uM CAS No.: [31966-52-6]

    2'- O- Monosuccinyladenosine- 3', 5'- cyclic monophosphate ( 2'-O-MS-cAMP )
       Cyclic AMP analogue, suitable for coupling of various ligands including proteins for ELISA. For a structure with a hydrolytically and enzymatically much more
       stable linkage please compare 2'-AHC-cAMP (Cat. No. A 046).
       Horton et al., J. Immun. Methods, 155, 31 - 40 (1992).
    M 011 25 uM/ ~11 mg, 5 x 25 uM CAS No.: [36940-87-1]